Se ha publicado recientemente en JACC este magnífico trabajo sobre los eventos y modo de muerte de los pacientes con insuficiencia cardiaca y fracción de eyección preservada, que va acompañado de una revisión sobre diferentes aspectos de esta enfermedad. Como resumen, reproducimos literalmente las conclusiones de los autores: “Only a minority of contemporary HFpEF studies captures cause-specific events. Among this subset, CV causes account for the majority of mortal events, but wide variation exists between RCTs and nonrandomized cohorts. Current event definitions have been directly applied from HFrEF studies. Reporting of mode of death must be revised and tailored to the HFpEF population, in order to better reflect prevalent causes of death observed in clinical practice. Broad-scale systematic autopsies and long-term rhythm monitoring may clarify the underlying pathology and mechanisms driving mortal events. There is an unmet need for a longitudinal multicenter, global registry of inpatients and outpatients with HFpEF to map its natural history. Developing a deeper understanding of cause-specific patterns of mortality in HFpEF may improve our understanding of the pathophysiology of this entity, and guide near-term drug and device development. Matching available and novel therapies with specific mechanisms of death may be a more successful therapeutic strategy in HFpEF moving forward”.
Referencias:
- J Am Coll Cardiol. - Mode of Death in Heart Failure With Preserved Ejection Fraction.
