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ESPACIO Prevención y Rehabilitación

Biblioteca de referencias

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ESPACIO de prevención y rehabilitación cardiovascular › Bloque I › I4

Guías y evidencia

Lo que recomiendan las guías y lo que demuestran los estudios, separando siempre lo aprobado de lo que se investiga.

I4

Todas las fuentes citadas en el ESPACIO, en formato Vancouver, con DOI y PMID verificados, filtrables por tema y descargables para un gestor bibliográfico.

La evidencia en el tiempo: los artículos y guías citados en este ESPACIO, por año

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711referencias: 670 artículos y guías, comprobados en PubMed y Crossref, y 41 fichas técnicas223de 2024, 2025 y 202696guías, consensos y declaraciones científicas

La lista se hace sola con lo que citan las páginas de este ESPACIO y se descarga en RIS.

Descargar en RIS (711 referencias)

Artículos y guías en PubMed (665)

  1. Abraham LN, Sibilitz KL, Berg SK, Tang LH, Risom SS, Lindschou J, et al. Exercise-based cardiac rehabilitation for adults after heart valve surgery. Cochrane Database Syst Rev. 2021;5(5):CD010876. doi:10.1002/14651858.CD010876.pub3 · PMID 33962483F4
  2. Abreu A, Pesah E, Supervia M, Turk-Adawi K, Bjarnason-Wehrens B, Lopez-Jimenez F, et al. Cardiac rehabilitation availability and delivery in Europe: How does it differ by region and compare with other high-income countries?: Endorsed by the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2019;26(11):1131-1146. doi:10.1177/2047487319827453 · PMID 30782007C1D6F9I3
  3. Abreu A, Frederix I, Dendale P, Janssen A, Doherty P, Piepoli MF, et al. Standardization and quality improvement of secondary prevention through cardiovascular rehabilitation programmes in Europe: The avenue towards EAPC accreditation programme: A position statement of the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology (EAPC). Eur J Prev Cardiol. 2021;28(5):496-509. doi:10.1177/2047487320924912 · PMID 33611459C3C4F2F3F9I1
  4. Adusumalli S, Jolly E, Chokshi NP, Gitelman Y, Rareshide CAL, Kolansky DM, et al. Referral Rates for Cardiac Rehabilitation Among Eligible Inpatients After Implementation of a Default Opt-Out Decision Pathway in the Electronic Medical Record. JAMA Netw Open. 2021;4(1):e2033472. doi:10.1001/jamanetworkopen.2020.33472 · PMID 33443579D3
  5. Aguiar-Ricardo I, Inácio Cazeiro D, Alves da Silva P, Sena Silva C, Abrantes A, Cunha N, et al. All-cause mortality benefits of attending phase 3 cardiac rehabilitation: A systematic review. Rev Port Cardiol. 2026;45(9):513-523. doi:10.1016/j.repc.2025.11.014 · PMID 42556784D4
  6. Ahmadi MN, Coenen P, Straker L, Stamatakis E. Device-measured stationary behaviour and cardiovascular and orthostatic circulatory disease incidence. Int J Epidemiol. 2024;53(6). doi:10.1093/ije/dyae136 · PMID 39412356E2
  7. Aimo A, Saccaro LF, Borrelli C, Fabiani I, Gentile F, Passino C, et al. The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease. Eur J Heart Fail. 2021;23(9):1458-1467. doi:10.1002/ejhf.2298 · PMID 34268843D5D7
  8. Ajufo E, Kany S, Rämö JT, Churchill TW, Guseh JS, Aragam KG, et al. Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease. J Am Coll Cardiol. 2025;85(5):473-486. doi:10.1016/j.jacc.2024.10.065 · PMID 39545903E2
  9. Aktürk Z, Hapfelmeier A, Fomenko A, Dümmler D, Eck S, Olm M, et al. Generalized Anxiety Disorder 7-item (GAD-7) and 2-item (GAD-2) scales for detecting anxiety disorders in adults. Cochrane Database Syst Rev. 2025;3(3):CD015455. doi:10.1002/14651858.CD015455 · PMID 40130828E5
  10. Alahmad B, Khraishah H, Royé D, Vicedo-Cabrera AM, Guo Y, Papatheodorou SI, et al. Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries. Circulation. 2023;147(1):35-46. doi:10.1161/CIRCULATIONAHA.122.061832 · PMID 36503273E7
  11. Ali LAM, El-Heneidy A, Taylor J, Redfern J, Gallagher R, Candelaria D, et al. Cardiac rehabilitation programme accreditation and certification: Comparing international practices, mapping standards, benchmarks, and future directions - A scoping review. Eur Heart J Qual Care Clin Outcomes. 2026. doi:10.1093/ehjqcco/qcag131 · PMID 42633963F9
  12. Ambrosetti M, Abreu A, Corrà U, Davos CH, Hansen D, Frederix I, et al. Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2021;28(5):460-495. doi:10.1177/2047487320913379 · PMID 33611446F2F3I1
  13. Amedro P, Gavotto A, Huguet H, Souilla L, Huby AC, Matecki S, et al. Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial. Eur Heart J. 2024;45(16):1458-1473. doi:10.1093/eurheartj/ehae085 · PMID 38430485F4F7I2
  14. Amjad MM, Khan MM, Sarwar F, Ali A, Ali M, Bakhash F, et al. Efficacy and Safety of Dual GLP-1/Glucagon Receptor Agonism in Overweight and Obesity: A Class-Specific Systematic Review and Meta-Analysis. Diabetes Obes Metab. 2026;28(12):11872-11890. doi:10.1111/dom.71400 · PMID 42811393I5
  15. Anderson CS, Hua C, Wang Z, Wang C, Jiang C, Liu R, et al. Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China. Lancet. 2025;406(10507):1020-1031. doi:10.1016/S0140-6736(25)01485-0 · PMID 40897187I2
  16. Anderson L, Brown JP, Clark AM, Dalal H, Rossau HK, Bridges C, et al. Patient education in the management of coronary heart disease. Cochrane Database Syst Rev. 2017;6(6):CD008895. doi:10.1002/14651858.CD008895.pub3 · PMID 28658719E6
  17. Anderson L, Nguyen TT, Dall CH, Burgess L, Bridges C, Taylor RS. Exercise-based cardiac rehabilitation in heart transplant recipients. Cochrane Database Syst Rev. 2017;4(4):CD012264. doi:10.1002/14651858.CD012264.pub2 · PMID 28375548F4
  18. Angelis A, Chrysohoou C, Tzorovili E, Laina A, Xydis P, Terzis I, et al. The Mediterranean Diet Benefit on Cardiovascular Hemodynamics and Erectile Function in Chronic Heart Failure Male Patients by Decoding Central and Peripheral Vessel Rheology. Nutrients. 2020;13(1). doi:10.3390/nu13010108 · PMID 33396861E7
  19. Angermann CE, Gelbrich G, Störk S, Gunold H, Edelmann F, Wachter R, et al. Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial. JAMA. 2016;315(24):2683-93. doi:10.1001/jama.2016.7635 · PMID 27367876E5I2
  20. Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. Lancet. 2016;387(10037):2507-20. doi:10.1016/S0140-6736(16)30272-0 · PMID 27116918E4E8I2
  21. Antithrombotic Trialists' (ATT) Collaboration, Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373(9678):1849-60. doi:10.1016/S0140-6736(09)60503-1 · PMID 19482214E8I2
  22. Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation. 2004;110(5):588-636. doi:10.1161/01.CIR.0000134791.68010.FA · PMID 15289388B3
  23. Antoniou V, Kapreli E, Davos CH, Batalik L, Pepera G. Safety and long-term outcomes of remote cardiac rehabilitation in coronary heart disease patients: A systematic review. Digit Health. 2024;10:20552076241237661. doi:10.1177/20552076241237661 · PMID 38533308F6
  24. Aranceta-Bartrina J, Pérez-Rodrigo C, Alberdi-Aresti G, Ramos-Carrera N, Lázaro-Masedo S. Prevalence of General Obesity and Abdominal Obesity in the Spanish Adult Population (Aged 25-64 Years) 2014-2015: The ENPE Study. Rev Esp Cardiol (Engl Ed). 2016;69(6):579-87. doi:10.1016/j.rec.2016.02.009 · PMID 27133458D6I3
  25. Arbelo E, Protonotarios A, Gimeno JR, Arbustini E, Barriales-Villa R, Basso C, et al. 2023 ESC Guidelines for the management of cardiomyopathies. Eur Heart J. 2023;44(37):3503-3626. doi:10.1093/eurheartj/ehad194 · PMID 37622657F4
  26. Arias Labrador E, Vilaró Casamitjana J, Blanco Díaz S, Brugué Pascual E, Buxó Pujolràs M, Grau JI, et al. Efectos de un programa de rehabilitación cardíaca fase iii en la capacidad funcional y composición corporal en pacientes con cardiopatía isquémica. Rehabilitacion (Madr). 2023;57(3):100764. doi:10.1016/j.rh.2022.10.003 · PMID 36437126D4
  27. Armario P, Brotons C, Elosua R, Alonso de Leciñana M, Castro A, Clarà A, et al. Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines. Clin Investig Arterioscler. 2021;33(2):85-107. doi:10.1016/j.arteri.2020.11.004 · PMID 33495044I1
  28. Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140(11):e596-e646. doi:10.1161/CIR.0000000000000678 · PMID 30879355B7I1
  29. Aronne LJ, Sattar N, Horn DB, Bays HE, Wharton S, Lin WY, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA. 2024;331(1):38-48. doi:10.1001/jama.2023.24945 · PMID 38078870E8
  30. Aronne LJ, Horn DB, le Roux CW, Ho W, Falcon BL, Gomez Valderas E, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025;393(1):26-36. doi:10.1056/NEJMoa2416394 · PMID 40353578B7E3E8I2
  31. Aronne LJ, Horn DB, le Roux CW, Chao AM, Ho W, Halpern B, et al. Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Nat Med. 2026;32(7):2679-2687. doi:10.1038/s41591-026-04386-7 · PMID 42120723I5
  32. Arrarte Esteban V, Campuzano Ruiz R, De Pablo Zarzosa C, Fernández Olmo MR, investigators of the AULARC registry. The state of cardiac rehabilitation in Spain. Results of the AULARC registry. Rev Esp Cardiol (Engl Ed). 2024;77(9):796-798. doi:10.1016/j.rec.2024.04.014 · PMID 38844071C3C4D6E5F9F10I3
  33. ASCEND Study Collaborative Group, Bowman L, Mafham M, Wallendszus K, Stevens W, Buck G, et al. Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. N Engl J Med. 2018;379(16):1529-1539. doi:10.1056/NEJMoa1804988 · PMID 30146931E8I2
  34. Ashor AW, Lara J, Siervo M, Celis-Morales C, Oggioni C, Jakovljevic DG, et al. Exercise modalities and endothelial function: a systematic review and dose-response meta-analysis of randomized controlled trials. Sports Med. 2015;45(2):279-96. doi:10.1007/s40279-014-0272-9 · PMID 25281334D5
  35. Ashur C, Cascino TM, Lewis C, Townsend W, Sen A, Pekmezi D, et al. Do Wearable Activity Trackers Increase Physical Activity Among Cardiac Rehabilitation Participants? A SYSTEMATIC REVIEW AND META-ANALYSIS. J Cardiopulm Rehabil Prev. 2021;41(4):249-256. doi:10.1097/HCR.0000000000000592 · PMID 33828045E2
  36. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111-7. doi:10.1164/ajrccm.166.1.at1102 · PMID 12091180F3
  37. Aubin HJ, Farley A, Lycett D, Lahmek P, Aveyard P. Weight gain in smokers after quitting cigarettes: meta-analysis. BMJ. 2012;345:e4439. doi:10.1136/bmj.e4439 · PMID 22782848E4
  38. Auer R, Schoeni A, Humair JP, Jacot-Sadowski I, Berlin I, Stuber MJ, et al. Electronic Nicotine-Delivery Systems for Smoking Cessation. N Engl J Med. 2024;390(7):601-610. doi:10.1056/NEJMoa2308815 · PMID 38354139I2
  39. Baena-Díez JM, Félix FJ, Grau M, Cabrera de León A, Sanz H, Leal M, et al. Tratamiento y control de los factores de riesgo según el riesgo coronario en la población española del estudio DARIOS. Rev Esp Cardiol. 2011;64(9):766-73. doi:10.1016/j.recesp.2011.04.019 · PMID 21764497I3
  40. Balata M, Gbreel MI, Elrashedy AA, Westenfeld R, Pfister R, Zimmer S, et al. Clinical effects of cognitive behavioral therapy in heart failure patients: a meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2023;23(1):280. doi:10.1186/s12906-023-04117-2 · PMID 37550665E5
  41. Banach M, Lewek J, Surma S, Penson PE, Sahebkar A, Martin SS, et al. The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. Eur J Prev Cardiol. 2023;30(18):1975-1985. doi:10.1093/eurjpc/zwad229 · PMID 37555441E2
  42. Banegas JR, Graciani A, de la Cruz-Troca JJ, León-Muñoz LM, Guallar-Castillón P, Coca A, et al. Achievement of cardiometabolic goals in aware hypertensive patients in Spain: a nationwide population-based study. Hypertension. 2012;60(4):898-905. doi:10.1161/HYPERTENSIONAHA.112.193078 · PMID 22949530D6I3
  43. Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005;111(20):2684-98. doi:10.1161/CIRCULATIONAHA.104.492215 · PMID 15911719E4
  44. Barth J, Jacob T, Daha I, Critchley JA. Psychosocial interventions for smoking cessation in patients with coronary heart disease. Cochrane Database Syst Rev. 2015;2015(7):CD006886. doi:10.1002/14651858.CD006886.pub2 · PMID 26148115E4I2
  45. Basu J, Nikoletou D, Miles C, MacLachlan H, Parry-Williams G, Tilby-Jones F, et al. High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial. Eur Heart J. 2025;46(19):1803-1815. doi:10.1093/eurheartj/ehae919 · PMID 40037382F4
  46. Batalik L, Filakova K, Sladeckova M, Dosbaba F, Su J, Pepera G. The cost-effectiveness of exercise-based cardiac telerehabilitation intervention: a systematic review. Eur J Phys Rehabil Med. 2023;59(2):248-258. doi:10.23736/S1973-9087.23.07773-0 · PMID 36692413F9
  47. Batalik L, Chamradova K, Winnige P, Dosbaba F, Batalikova K, Vlazna D, et al. Effect of exercise-based cancer rehabilitation via telehealth: a systematic review and meta-analysis. BMC Cancer. 2024;24(1):600. doi:10.1186/s12885-024-12348-w · PMID 38760805F7
  48. Batsis JA, Gavras A, Gross DC, Cheever CR, Da Silva BR, Meira Filho LF, et al. Effect of Incretin-Based and Nonpharmacologic Weight Loss on Body Composition : A Systematic Review. Ann Intern Med. 2026;179(7):996-1013. doi:10.7326/ANNALS-25-00478 · PMID 41996180E3
  49. Beauchamp A, Talevski J, Niebauer J, Gutenberg J, Kefalianos E, Mayr B, et al. Health literacy interventions for secondary prevention of coronary artery disease: a scoping review. Open Heart. 2022;9(1). doi:10.1136/openhrt-2021-001895 · PMID 35064057E6
  50. Behrouzi B, Bhatt DL, Cannon CP, Vardeny O, Lee DS, Solomon SD, et al. Association of Influenza Vaccination With Cardiovascular Risk: A Meta-analysis. JAMA Netw Open. 2022;5(4):e228873. doi:10.1001/jamanetworkopen.2022.8873 · PMID 35486404I2
  51. Bellido V, le Roux CW, Ekinci EI, Bjornstad P, Frias JP, Giblin K, et al. Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial. Lancet. 2026;408(10563):1455-1472. doi:10.1016/S0140-6736(26)01861-1 · PMID 42810372I5
  52. Benowitz NL, Pipe A, West R, Hays JT, Tonstad S, McRae T, et al. Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(5):622-631. doi:10.1001/jamainternmed.2018.0397 · PMID 29630702E4E8I2
  53. Benzer W, Rauch B, Schmid JP, Zwisler AD, Dendale P, Davos CH, et al. Exercise-based cardiac rehabilitation in twelve European countries results of the European cardiac rehabilitation registry. Int J Cardiol. 2017;228:58-67. doi:10.1016/j.ijcard.2016.11.059 · PMID 27863363I3
  54. Berg SK, Pedersen PU, Zwisler AD, Winkel P, Gluud C, Pedersen BD, et al. Comprehensive cardiac rehabilitation improves outcome for patients with implantable cardioverter defibrillator. Findings from the COPE-ICD randomised clinical trial. Eur J Cardiovasc Nurs. 2015;14(1):34-44. doi:10.1177/1474515114521920 · PMID 24504872F4
  55. Berg SK, Thorup CB, Borregaard B, Christensen AV, Thrysoee L, Rasmussen TB, et al. Patient-reported outcomes are independent predictors of one-year mortality and cardiac events across cardiac diagnoses: Findings from the national DenHeart survey. Eur J Prev Cardiol. 2019;26(6):624-637. doi:10.1177/2047487318769766 · PMID 29638142E6
  56. Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA. 2003;289(23):3106-16. doi:10.1001/jama.289.23.3106 · PMID 12813116I2
  57. Bhatt AS, Liu VX, Sun B, Apostol-Largeteau M, Marafino BJ, Amiri M, et al. Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial. JAMA. 2026;336(17):1518-1528. doi:10.1001/jama.2026.16372 · PMID 42667613D4
  58. Bhatt DL, Eagle KA, Ohman EM, Hirsch AT, Goto S, Mahoney EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010;304(12):1350-7. doi:10.1001/jama.2010.1322 · PMID 20805624D1
  59. Bihrmann K, Ersbøll AK, Svendsen ML, Søndergaard H, Zwisler AD. Uptake and Inequalities in Exercise-Based Cardiac Rehabilitation After Decentralization. JAMA Netw Open. 2026;9(10):e2639054. doi:10.1001/jamanetworkopen.2026.39054 · PMID 42873496F9
  60. Bijkerk S, Ponte-Negretti CI, Maung KK, Friedrichs LG, Alegre-Díaz J, Anderson SG, et al. Development and external validation of the SCORE2 models in Latin America and the Caribbean (SCORE2-LAC) to estimate 10-year cardiovascular disease risk. Eur Heart J. 2026. doi:10.1093/eurheartj/ehag698 · PMID 42667259B7D1
  61. Bjarnason-Wehrens B, McGee H, Zwisler AD, Piepoli MF, Benzer W, Schmid JP, et al. Cardiac rehabilitation in Europe: results from the European Cardiac Rehabilitation Inventory Survey. Eur J Cardiovasc Prev Rehabil. 2010;17(4):410-8. doi:10.1097/HJR.0b013e328334f42d · PMID 20300001I3
  62. Blacher J, Olié V, Gabet A, Cinaud A, Tuppin P, Iliou MC, et al. Two-year prognosis and cardiovascular disease prevention after acute coronary syndrome: the role of cardiac rehabilitation-a French nationwide study. Eur J Prev Cardiol. 2024;31(16):1939-1947. doi:10.1093/eurjpc/zwae194 · PMID 38832727I3
  63. Blumenthal JA, Babyak MA, O'Connor C, Keteyian S, Landzberg J, Howlett J, et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA. 2012;308(5):465-74. doi:10.1001/jama.2012.8720 · PMID 22851113E5
  64. Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Smith PJ, Hoffman BM, et al. Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. J Am Coll Cardiol. 2012;60(12):1053-63. doi:10.1016/j.jacc.2012.04.040 · PMID 22858387D5
  65. Blumenthal JA, Sherwood A, Smith PJ, Watkins L, Mabe S, Kraus WE, et al. Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial. Circulation. 2016;133(14):1341-50. doi:10.1161/CIRCULATIONAHA.115.018926 · PMID 27045127I2
  66. Borde R, Hortobágyi T, Granacher U. Dose-Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis. Sports Med. 2015;45(12):1693-720. doi:10.1007/s40279-015-0385-9 · PMID 26420238E1
  67. Boriani G, Imberti JF, Bonini N, Carriere C, Mei DA, Zecchin M, et al. Remote multiparametric monitoring and management of heart failure patients through cardiac implantable electronic devices. Eur J Intern Med. 2023;115:1-9. doi:10.1016/j.ejim.2023.04.011 · PMID 37076404F8
  68. Boston D, Larson AE, Sheppler CR, O'Connor PJ, Sperl-Hillen JM, Hauschildt J, et al. Does Clinical Decision Support Increase Appropriate Medication Prescribing for Cardiovascular Risk Reduction? J Am Board Fam Med. 2023;36(5):777-788. doi:10.3122/jabfm.2022.220391R2 · PMID 37704387F8
  69. Bouakkar J, Pereira TJ, Johnston H, Pakosh M, Drake JDM, Edgell H. Sex differences in the physiological responses to cardiac rehabilitation: a systematic review. BMC Sports Sci Med Rehabil. 2024;16(1):74. doi:10.1186/s13102-024-00867-9 · PMID 38549168F4
  70. Bricca A, Aadahl M, Skou ST, Thornton JS, Bandholm T, Midtgaard J, et al. ACTIVATE: physical activity assessment, prescription and promotion in clinical practice by healthcare professionals - a consensus study initiated by the International Federation of Sports Physical Therapy. Br J Sports Med. 2026;60(9):629-639. doi:10.1136/bjsports-2025-110242 · PMID 41850727E2
  71. Brignole M, Moya A, de Lange FJ, Deharo JC, Elliott PM, Fanciulli A, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39(21):1883-1948. doi:10.1093/eurheartj/ehy037 · PMID 29562304B3
  72. Brown TM, Pack QR, Aberegg E, Brewer LC, Ford YR, Forman DE, et al. Core Components of Cardiac Rehabilitation Programs: 2024 Update: A Scientific Statement From the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2024;150(18):e328-e347. doi:10.1161/CIR.0000000000001289 · PMID 39315436F9I1
  73. Brugts JJ, Radhoe SP, Clephas PRD, Aydin D, van Gent MWF, Szymanski MK, et al. Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial. Lancet. 2023;401(10394):2113-2123. doi:10.1016/S0140-6736(23)00923-6 · PMID 37220768F8
  74. Brørs G, Dalen H, Allore H, Deaton C, Fridlund B, Osborne RH, et al. Health Literacy and Risk Factors for Coronary Artery Disease (From the CONCARD(PCI) Study). Am J Cardiol. 2022;179:22-30. doi:10.1016/j.amjcard.2022.06.016 · PMID 35853782E6
  75. Buckley BJ, Long L, Risom SS, Lane DA, Berg SK, Gluud C, et al. Exercise-based cardiac rehabilitation for adults with atrial fibrillation. Cochrane Database Syst Rev. 2024;9(9):CD011197. doi:10.1002/14651858.CD011197.pub3 · PMID 39287086F4F7
  76. Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, et al. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee. Eur Heart J. 2025;46(41):4156-4225. doi:10.1093/eurheartj/ehaf191 · PMID 40878270B6E5I1
  77. Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451-1462. doi:10.1136/bjsports-2020-102955 · PMID 33239350B7E2I1
  78. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-3826. doi:10.1093/eurheartj/ehad191 · PMID 37622654B4B6C4D1D2D3D4E4E5E7E8F4I1
  79. Bäck M, Leosdottir M, Hagström E, Norhammar A, Hag E, Jernberg T, et al. The SWEDEHEART secondary prevention and cardiac rehabilitation registry (SWEDEHEART CR registry). Eur Heart J Qual Care Clin Outcomes. 2021;7(5):431-437. doi:10.1093/ehjqcco/qcab039 · PMID 34097023I3
  80. Bäck M, Leosdottir M, James S, Hagström E. Cardiac Rehabilitation Registries as Tools for Quality Improvement and Research: Insights From the SWEDEHEART-CR registry. Can J Cardiol. 2025;41(12S):S68-S74. doi:10.1016/j.cjca.2025.09.039 · PMID 41448729I3
  81. Bäck M, Wilhelm M, Marcin T, Machado FVC, Sandberg A, Buccheri S, et al. 2026 ESC Guidelines on cardiac rehabilitation. Eur Heart J. 2026;47(39):5631-5729. doi:10.1093/eurheartj/ehag099 · PMID 42661418B3B4B6B7C1C2C4D1D2D3D4D5E1E2E3E4E5E6E7E8F2F3F4F5F6F7F8F9I1I2I5
  82. Bäck M, Wilhelm M, Marcin T, Machado FVC, Sandberg A, Buccheri S, et al. 2026 ESC Guidelines on cardiac rehabilitation. Eur J Prev Cardiol. 2026. doi:10.1093/eurjpc/zwag417 · PMID 42661424I1
  83. Cabrera-Aguilera I, Ivern C, Badosa N, Marco E, Salas-Medina L, Mojón D, et al. Impact of and Reasons for Not Performing Exercise Training After an Acute Coronary Syndrome in the Setting of an Interdisciplinary Cardiac Rehabilitation Program: Results From a Risk-Op- Acute Coronary Syndrome Ambispective Registry. Front Physiol. 2021;12:768199. doi:10.3389/fphys.2021.768199 · PMID 34899392I3
  84. Camarelles Guillem F, Minué Lorenzo C, Córdoba Garcia R. Efectividad del programa de financiación de la deshabituación tabáquica en la sanidad pública. Aten Primaria. 2025;57(11):103384. doi:10.1016/j.aprim.2025.103384 · PMID 40992224F11
  85. Castellano JM, Sanz G, Peñalvo JL, Bansilal S, Fernández-Ortiz A, Alvarez L, et al. A polypill strategy to improve adherence: results from the FOCUS project. J Am Coll Cardiol. 2014;64(20):2071-82. doi:10.1016/j.jacc.2014.08.021 · PMID 25193393I2
  86. Castellano JM, Pocock SJ, Bhatt DL, Quesada AJ, Owen R, Fernandez-Ortiz A, et al. Polypill Strategy in Secondary Cardiovascular Prevention. N Engl J Med. 2022;387(11):967-977. doi:10.1056/NEJMoa2208275 · PMID 36018037D2D4E8I2
  87. Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. doi:10.1016/j.clnu.2016.09.004 · PMID 27642056E3
  88. Cequier Á, Bueno H, Macaya C, Bertomeu V, González-Juanatey JR, Íñiguez A, et al. Trends in cardiovascular care in the National Health System in Spain. Data from the RECALCAR project 2011-2020. Rev Esp Cardiol (Engl Ed). 2023;76(7):519-530. doi:10.1016/j.rec.2022.09.017 · PMID 36493955D6I3
  89. Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr, et al. Use of sildenafil in patients with cardiovascular disease. Technology and Practice Executive Committee. Circulation. 1999;99(1):168-77. doi:10.1161/01.cir.99.1.168 · PMID 9884398E7
  90. Chen X, Zhang T, Hu X, Wen Z, Lu W, Jiang W. High-Intensity Interval Training Programs Versus Moderate-Intensity Continuous Training for Individuals With Heart Failure: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2025;106(1):98-112. doi:10.1016/j.apmr.2024.05.028 · PMID 38862032E1
  91. Chew DS, Whitelaw S, Vaduganathan M, Mark DB, Van Spall HGC. Patient-Reported Outcome Measures in Cardiovascular Disease: An Evidence Map of the Psychometric Properties of Health Status Instruments. Ann Intern Med. 2022;175(10):1431-1439. doi:10.7326/M22-2234 · PMID 36122377E6
  92. Choi KH, Park YH, Lee JY, Jeong JO, Kim CJ, Yun KH, et al. Efficacy and safety of clopidogrel versus aspirin monotherapy in patients at high risk of subsequent cardiovascular event after percutaneous coronary intervention (SMART-CHOICE 3): a randomised, open-label, multicentre trial. Lancet. 2025;405(10486):1252-1263. doi:10.1016/S0140-6736(25)00449-0 · PMID 40174599E8
  93. Chowdhury M, Heald FA, Sanchez-Delgado JC, Pakosh M, Jacome-Hortua AM, Grace SL. The effects of maintenance cardiac rehabilitation: A systematic review and Meta-analysis, with a focus on sex. Heart Lung. 2021;50(4):504-524. doi:10.1016/j.hrtlng.2021.02.016 · PMID 33836441D4
  94. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol. 2004;44(1):152-8. doi:10.1016/j.jacc.2004.03.039 · PMID 15234425D5
  95. Cinza Sanjurjo S, Prieto Díaz MÁ, Llisterri Caro JL, Pallarés Carratalá V, Barquilla García A, Rodríguez Padial L, et al. Características basales y manejo clínico de los primeros 3.000 pacientes incluidos en el estudio IBERICAN (Identificación de la población española de riesgo cardiovascular y renal). Semergen. 2017;43(7):493-500. doi:10.1016/j.semerg.2016.07.006 · PMID 27567214D6I3
  96. Cinza Sanjurjo S, Llisterri Caro JL, Barquilla García A, Polo García J, Velilla Zancada S, Rodríguez Roca GC, et al. Descripción de la muestra, diseño y métodos del estudio para la identificación de la población española de riesgo cardiovascular y renal (IBERICAN). Semergen. 2020;46(1):4-15. doi:10.1016/j.semerg.2019.10.006 · PMID 31870705I3
  97. Cinza-Sanjurjo S, Micó-Pérez RM, Velilla-Zancada S, Prieto-Díaz MA, Rodríguez-Roca GC, Barquilla García A, et al. Factores asociados al riesgo cardiovascular y enfermedad cardiovascular y renal en el estudio IBERICAN (Identificación de la poBlación Española de RIesgo CArdiovascular y reNal): resultados definitivos. Semergen. 2020;46(6):368-378. doi:10.1016/j.semerg.2020.06.027 · PMID 32873502I3
  98. Cinza-Sanjurjo S, Prieto-Díaz MA, Pallares-Carratala V, Mico-Pérez RM, Barquilla-García A, Velilla-Zancada SM, et al. Prevalence of obesity in primary care patients: The IBERICAN study. Nutr Metab Cardiovasc Dis. 2025;35(5):103751. doi:10.1016/j.numecd.2024.09.021 · PMID 39638674D6I3
  99. Clair C, Rigotti NA, Porneala B, Fox CS, D'Agostino RB, Pencina MJ, et al. Association of smoking cessation and weight change with cardiovascular disease among adults with and without diabetes. JAMA. 2013;309(10):1014-21. doi:10.1001/jama.2013.1644 · PMID 23483176E4
  100. Clarkesmith DE, Pattison HM, Khaing PH, Lane DA. Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation. Cochrane Database Syst Rev. 2017;4(4):CD008600. doi:10.1002/14651858.CD008600.pub3 · PMID 28378924E6
  101. Coenen P, Huysmans MA, Holtermann A, Troiano RP, Mork PJ, Krokstad S, et al. Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis. Br J Sports Med. 2024;58(24):1527-1538. doi:10.1136/bjsports-2024-108117 · PMID 39255999E2
  102. Conraads VM, Pattyn N, De Maeyer C, Beckers PJ, Coeckelberghs E, Cornelissen VA, et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: the SAINTEX-CAD study. Int J Cardiol. 2015;179:203-10. doi:10.1016/j.ijcard.2014.10.155 · PMID 25464446I2
  103. Coppi F, Pagnoni G, Vicenzi A, Darroudi S, Savino G, Zurlo C, et al. Long-Term Attrition in a 12-Month Adapted Physical Activity Program After Cardiac Rehabilitation: A Real-World Longitudinal Study. J Cardiovasc Dev Dis. 2026;13(9). doi:10.3390/jcdd13090418 · PMID 42783025D4
  104. Cornelissen V, Hanssen H, Hurst C, Knaier R, Marques-Sule E, Moholdt T, et al. Influence of exercise and nutrition on sarcopenia in cardiovascular disease: a Scientific Statement of the European Association of Preventive Cardiology of the European Society of Cardiology. Eur J Prev Cardiol. 2026;33(12):2105-2126. doi:10.1093/eurjpc/zwaf432 · PMID 40663695E3
  105. Correction to: 2026 ESC Guidelines on cardiac rehabilitation: Developed by the task force on cardiac rehabilitation of the European Society of Cardiology (ESC)Endorsed by the European Society of Physical and Rehabilitation Medicine (ESPRM) and World Organization of Family Doctors (WONCA). Eur Heart J. 2026. doi:10.1093/eurheartj/ehag887 · PMID 42921976C1D2E2E3E5E6F2F4F9I1I5
  106. Costa R, Moreira E, Silva Cardoso J, Azevedo LF, Ribeiro JA, Pinto R. Effectiveness of Exercise-Based Cardiac Rehabilitation for Heart Transplant Recipients: A Systematic Review and Meta-Analysis. Health Serv Insights. 2023;16:11786329231161482. doi:10.1177/11786329231161482 · PMID 36968658F4
  107. Courneya KS, Vardy JL, O'Callaghan CJ, Gill S, Friedenreich CM, Wong RKS, et al. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer. N Engl J Med. 2025;393(1):13-25. doi:10.1056/NEJMoa2502760 · PMID 40450658F4
  108. Courtney RJ, McRobbie H, Tutka P, Weaver NA, Petrie D, Mendelsohn CP, et al. Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial. JAMA. 2021;326(1):56-64. doi:10.1001/jama.2021.7621 · PMID 34228066E8
  109. Coutinho T, Khadanga S, Adedinsewo D, Barac A, Brown TM, Deaton C, et al. Cardiac Rehabilitation in Women: A Scientific Statement From the American Heart Association. Circulation. 2025;152(19):e376-e390. doi:10.1161/CIR.0000000000001379 · PMID 41084821F4
  110. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review. JAMA. 2003;290(1):86-97. doi:10.1001/jama.290.1.86 · PMID 12837716D5E4E8
  111. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169 · PMID 30312372E3F3
  112. Currier BS, D'Souza AC, Singh MAF, Lowisz CV, Rawson ES, Schoenfeld BJ, et al. American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews. Med Sci Sports Exerc. 2026;58(4):851-872. doi:10.1249/MSS.0000000000003897 · PMID 41843416E1
  113. Córdoba García R, Camarelles Guillem F, Muñoz Seco E, Gómez Puente JM, San José Arango J, Ramírez Manent JI, et al. Recomendaciones sobre el estilo de vida. Actualización PAPPS 2024. Aten Primaria. 2024;56 Suppl 1(Suppl 1):103133. doi:10.1016/j.aprim.2024.103133 · PMID 39613361B4E4
  114. d'Entremont MA, Poorthuis MHF, Fiolet ATL, Amarenco P, Boczar KE, Buysschaert I, et al. Colchicine for secondary prevention of vascular events: a meta-analysis of trials. Eur Heart J. 2025;46(26):2564-2575. doi:10.1093/eurheartj/ehaf210 · PMID 40314334E8
  115. Dahabreh IJ, Paulus JK. Association of episodic physical and sexual activity with triggering of acute cardiac events: systematic review and meta-analysis. JAMA. 2011;305(12):1225-33. doi:10.1001/jama.2011.336 · PMID 21427375E7
  116. Dal Passo B, Tonet E, Raisi A, Zagnoni S, Chiaranda G, Pasanisi G, et al. Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial. Circ Popul Health Outcomes. 2026;19(9):e013410. doi:10.1161/CIRCOUTCOMES.126.013410 · PMID 42605666F4
  117. Dalal HM, Taylor RS, Jolly K, Davis RC, Doherty P, Miles J, et al. The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: The REACH-HF multicentre randomized controlled trial. Eur J Prev Cardiol. 2019;26(3):262-272. doi:10.1177/2047487318806358 · PMID 30304644I2
  118. Dalli-Peydró E, Prades Martí M, Tuzón-Segarra MT, Fresneda-Fresneda A, Muñoz-Ramos N, Cosín-Sales J. Cost-utility of cardiac telerehabilitation versus conventional hospital rehabilitation after ACS in Spain. Rev Esp Cardiol (Engl Ed). 2024;77(1):99-101. doi:10.1016/j.rec.2023.07.014 · PMID 38165030F9
  119. Damman K, Ter Maaten JM, Mayne KJ, Bolignano D, Brown EM, da Costa BR, et al. 2026 ESC Guidelines for the management of cardiovascular disease and chronic kidney disease, in collaboration with the European Renal Association (ERA). Eur Heart J. 2026. doi:10.1093/eurheartj/ehag098 · PMID 42661426D1D2E4I1
  120. Davies MJ, Bajaj HS, Broholm C, Eliasen A, Garvey WT, le Roux CW, et al. Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes. N Engl J Med. 2025;393(7):648-659. doi:10.1056/NEJMoa2502082 · PMID 40544432I5
  121. De Backer G, De Bacquer D, Kotseva K, Rydén L, Wood D, EUROASPIRE Investigators. EUROASPIRE 1996-2026: 30 years of research into prevention of cardiovascular disease. Eur J Prev Cardiol. 2026. doi:10.1093/eurjpc/zwag282 · PMID 42669129I3
  122. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99(6):779-85. doi:10.1161/01.cir.99.6.779 · PMID 9989963I2
  123. Dedic E, Vistisen HS, Zwisler AD, Pedersen BF, Kappel KL, Kanstrup H, et al. Patients' acceptability of a patient-reported outcome measure in cardiac rehabilitation (the PRO-Heart-DK)-a mixed methods study using the Theoretical Framework of Acceptability. J Patient Rep Outcomes. 2025;9(1):35. doi:10.1186/s41687-024-00831-8 · PMID 40131675E6
  124. Del Pozo Cruz B, Ahmadi M, Sabag A, Saint Maurice PF, Lee IM, Stamatakis E. Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults. Ann Intern Med. 2025;178(12):1718-1727. doi:10.7326/ANNALS-25-01547 · PMID 41144973E2
  125. Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, Quintana-Navarro GM, Fuentes F, Garcia-Rios A, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet. 2022;399(10338):1876-1885. doi:10.1016/S0140-6736(22)00122-2 · PMID 35525255E3I2
  126. Dibben G, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2021;11(11):CD001800. doi:10.1002/14651858.CD001800.pub4 · PMID 34741536I2
  127. Dibben G, de Vries FB, Faulkner J, Oldridge N, Rees K, Stens NA, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2026;9(9):CD001800. doi:10.1002/14651858.CD001800.pub5 · PMID 42754260I2
  128. Dibben GO, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, et al. Exercise-based cardiac rehabilitation for coronary heart disease: a meta-analysis. Eur Heart J. 2023;44(6):452-469. doi:10.1093/eurheartj/ehac747 · PMID 36746187F4F9I2
  129. Diez-Quevedo C, Rangil T, Sanchez-Planell L, Kroenke K, Spitzer RL. Validation and utility of the patient health questionnaire in diagnosing mental disorders in 1003 general hospital Spanish inpatients. Psychosom Med. 2001;63(4):679-86. doi:10.1097/00006842-200107000-00021 · PMID 11485122E5
  130. Dilixiati D, Cao R, Mao Y, Li Y, Dilimulati D, Azhati B, et al. Association between cardiovascular disease and risk of female sexual dysfunction: a systematic review and meta-analysis. Eur J Prev Cardiol. 2024;31(7):782-800. doi:10.1093/eurjpc/zwae042 · PMID 38297501E7
  131. Ding D, Nguyen B, Nau T, Luo M, Del Pozo Cruz B, Dempsey PC, et al. Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis. Lancet Public Health. 2025;10(8):e668-e681. doi:10.1016/S2468-2667(25)00164-1 · PMID 40713949E2
  132. Do D, Lee T, Peasah SK, Good CB, Inneh A, Patel U. GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes. JAMA Netw Open. 2024;7(5):e2413172. doi:10.1001/jamanetworkopen.2024.13172 · PMID 38787563B7E3F5I5
  133. Dobbie LJ, Tolvanen L, Alves D, Baker JL, Bez NS, Birney S, et al. Nutritional, functional, and psychological considerations for incretin-based therapies in adults-an EASO, EFAD, and ECPO Consensus Statement. Lancet Diabetes Endocrinol. 2026;14(9):754-777. doi:10.1016/S2213-8587(26)00122-1 · PMID 42419343E3
  134. Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, et al. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obes Facts. 2022;15(3):321-335. doi:10.1159/000521241 · PMID 35196654E3
  135. Dorotheo EU, Arora M, Banerjee A, Bianco E, Cheah NP, Dalmau R, et al. Nicotine and Cardiovascular Health: When Poison is Addictive - a WHF Policy Brief. Glob Heart. 2024;19(1):14. doi:10.5334/gh.1292 · PMID 38312998B7
  136. Doundoulakis I, Farmakis IT, Theodoridis X, Konstantelos A, Christoglou M, Kotzakioulafi E, et al. Effects of dietary interventions on cardiovascular outcomes: a network meta-analysis. Nutr Rev. 2024;82(6):715-725. doi:10.1093/nutrit/nuad080 · PMID 37432782E3
  137. Doyle MP, Indraratna P, Tardo DT, Peeceeyen SC, Peoples GE. Safety and efficacy of aerobic exercise commenced early after cardiac surgery: A systematic review and meta-analysis. Eur J Prev Cardiol. 2019;26(1):36-45. doi:10.1177/2047487318798924 · PMID 30188177D3E1
  138. Duncan MS, Freiberg MS, Greevy RA Jr, Kundu S, Vasan RS, Tindle HA. Association of Smoking Cessation With Subsequent Risk of Cardiovascular Disease. JAMA. 2019;322(7):642-650. doi:10.1001/jama.2019.10298 · PMID 31429895E4
  139. Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, et al. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care. 2012;35(5):976-83. doi:10.2337/dc11-1931 · PMID 22374636E2
  140. Díaz-Balboa E, Peña-Gil C, Rodríguez-Romero B, Cuesta-Vargas AI, Lado-Baleato O, Martínez-Monzonís A, et al. Exercise-based cardio-oncology rehabilitation for cardiotoxicity prevention during breast cancer chemotherapy: The ONCORE randomized controlled trial. Prog Cardiovasc Dis. 2024;85:74-81. doi:10.1016/j.pcad.2024.02.002 · PMID 38395212F4
  141. Edelmann F, Wachter R, Duvinage A, Mueller S, Fegers-Wustrow I, Schwarz S, et al. Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial. Nat Med. 2025;31(1):306-314. doi:10.1038/s41591-024-03342-7 · PMID 39747684F4I2
  142. Edwards JJ, Deenmamode AHP, Griffiths M, Arnold O, Cooper NJ, Wiles JD, et al. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials. Br J Sports Med. 2023;57(20):1317-1326. doi:10.1136/bjsports-2022-106503 · PMID 37491419D5
  143. Edwardson CL, Biddle SJH, Clemes SA, Davies MJ, Dunstan DW, Eborall H, et al. Effectiveness of an intervention for reducing sitting time and improving health in office workers: three arm cluster randomised controlled trial. BMJ. 2022;378:e069288. doi:10.1136/bmj-2021-069288 · PMID 35977732E2
  144. Eisa N, Barood O. Lean Mass Changes With Incretin Therapy Versus Lifestyle Intervention: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Diabetes Obes Metab. 2026;28(6):4818-4827. doi:10.1111/dom.70666 · PMID 41877354E3
  145. Eisenberg MJ, Grandi SM, Gervais A, O'Loughlin J, Paradis G, Rinfret S, et al. Bupropion for smoking cessation in patients hospitalized with acute myocardial infarction: a randomized, placebo-controlled trial. J Am Coll Cardiol. 2013;61(5):524-32. doi:10.1016/j.jacc.2012.08.1030 · PMID 23369417E4E8
  146. Eisenberg MJ, Windle SB, Roy N, Old W, Grondin FR, Bata I, et al. Varenicline for Smoking Cessation in Hospitalized Patients With Acute Coronary Syndrome. Circulation. 2016;133(1):21-30. doi:10.1161/CIRCULATIONAHA.115.019634 · PMID 26553744D3E4E8I2
  147. Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, et al. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet. 2016;388(10051):1302-10. doi:10.1016/S0140-6736(16)30370-1 · PMID 27475271E2
  148. Ekelund U, Tarp J, Steene-Johannessen J, Hansen BH, Jefferis B, Fagerland MW, et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019;366:l4570. doi:10.1136/bmj.l4570 · PMID 31434697E2
  149. Ekelund U, Tarp J, Fagerland MW, Johannessen JS, Hansen BH, Jefferis BJ, et al. Joint associations of accelero-meter measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals. Br J Sports Med. 2020;54(24):1499-1506. doi:10.1136/bjsports-2020-103270 · PMID 33239356E2
  150. Ellingsen Ø, Halle M, Conraads V, Støylen A, Dalen H, Delagardelle C, et al. High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction. Circulation. 2017;135(9):839-849. doi:10.1161/CIRCULATIONAHA.116.022924 · PMID 28082387I2
  151. Ellis T, Cheng S, Lee C, Paramaguru P, Senthilnathan A, Chen HY, et al. Secondary Prevention Education Initiated in Hospital for People with Coronary Heart Disease: A Systematic Review and Meta-Analysis. Eur J Prev Cardiol. 2025. doi:10.1093/eurjpc/zwaf709 · PMID 41206592E6
  152. Eser P, Pini M, Vetsch T, Marcin T, Berni S, Burri R, et al. Comparison of patient characteristics and health outcomes between self-selected centre-based cardiac rehabilitation and hybrid cardiac telerehabilitation: a prospective cohort study. Eur J Prev Cardiol. 2026;33(6):829-838. doi:10.1093/eurjpc/zwaf107 · PMID 40184412F7
  153. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368(14):1279-90. doi:10.1056/NEJMoa1200303 · PMID 23432189I2
  154. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018;378(25):e34. doi:10.1056/NEJMoa1800389 · PMID 29897866E3I2
  155. Evins AE, Cather C, Reeder HT, Evohr B, Potter K, Pachas GN, et al. Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial. JAMA. 2025;333(21):1876-1886. doi:10.1001/jama.2025.3810 · PMID 40266580B7E4
  156. Fedewa MV, Hathaway ED, Ward-Ritacco CL. Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials. Br J Sports Med. 2017;51(8):670-676. doi:10.1136/bjsports-2016-095999 · PMID 27445361D5
  157. Fegers-Wustrow I, Haykowsky MJ, Winzer EB, Adams V, Wisloff U, Gevaert AB, et al. Sex Differences in Exercise Training Response Among HFpEF Patients: Pooled Analysis of OptimEx-Clin and Ex-DHF-Trials. Eur J Heart Fail. 2026. doi:10.1093/ejhf/xuag240 · PMID 42522564I2
  158. Feijoo L, Rey-Brandariz J, Guerra-Tort C, Candal-Pedreira C, Santiago-Pérez MI, Ruano-Ravina A, et al. Prevalence of obesity in Spain and its autonomous communities, 1987-2020. Rev Esp Cardiol (Engl Ed). 2024;77(10):809-818. doi:10.1016/j.rec.2023.12.018 · PMID 38490640D6I3
  159. Feuerstein A, Schoenrath F, Belyavskiy E, Knierim J, Friede T, Placzek M, et al. Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (Ex-VAD trial). Eur J Heart Fail. 2023;25(12):2252-2262. doi:10.1002/ejhf.3032 · PMID 37702315F4
  160. Fiolet ATL, Opstal TSJ, Mosterd A, Eikelboom JW, Jolly SS, Keech AC, et al. Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials. Eur Heart J. 2021;42(28):2765-2775. doi:10.1093/eurheartj/ehab115 · PMID 33769515I2
  161. Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018;15(12):731-743. doi:10.1038/s41569-018-0065-1 · PMID 30115967D5
  162. Fleg JL, Golbus JR, Afilalo J, Cornwell WK 3rd, Cuccurullo S, Dougherty CM, et al. Exercise Training in High-Risk Populations: A Scientific Statement From the American Heart Association. Circulation. 2026;154(8):e319-e338. doi:10.1161/CIR.0000000000001456 · PMID 42422933E1I1
  163. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128(8):873-934. doi:10.1161/CIR.0b013e31829b5b44 · PMID 23877260B3C3
  164. Flynn KE, Piña IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, et al. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1451-9. doi:10.1001/jama.2009.457 · PMID 19351942I2
  165. Fontes JP, Vilela EM, Durazzo A, Teixeira M. Current state of cardiac rehabilitation in Portugal: Results of the 2019 national survey. Rev Port Cardiol (Engl Ed). 2021;40(11):877-887. doi:10.1016/j.repce.2021.10.024 · PMID 34857162I3
  166. Foraker R, Sperling L, Bratzke L, Budoff M, Leppert M, Razavi AC, et al. Opportunistic Detection of Coronary Artery Calcium on Noncardiac Chest Computed Tomography: An Emerging Tool for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. 2025;152(19):e391-e401. doi:10.1161/CIR.0000000000001382 · PMID 41099128B7
  167. Foulkes SJ, Howden EJ, Haykowsky MJ, Antill Y, Salim A, Nightingale SS, et al. Exercise for the Prevention of Anthracycline-Induced Functional Disability and Cardiac Dysfunction: The BREXIT Study. Circulation. 2023;147(7):532-545. doi:10.1161/CIRCULATIONAHA.122.062814 · PMID 36342348F4
  168. Franssen WMA, Franssen GHLM, Spaas J, Solmi F, Eijnde BO. Can consumer wearable activity tracker-based interventions improve physical activity and cardiometabolic health in patients with chronic diseases? A systematic review and meta-analysis of randomised controlled trials. Int J Behav Nutr Phys Act. 2020;17(1):57. doi:10.1186/s12966-020-00955-2 · PMID 32393357E2
  169. Fröbert O, Götberg M, Erlinge D, Akhtar Z, Christiansen EH, MacIntyre CR, et al. Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. Circulation. 2021;144(18):1476-1484. doi:10.1161/CIRCULATIONAHA.121.057042 · PMID 34459211I2
  170. Gabet A, De Peretti C, Iliou MC, Nicolau J, Olié V. National trends in admission for cardiac rehabilitation after a myocardial infarction in France from 2010 to 2014. Arch Cardiovasc Dis. 2018;111(11):625-633. doi:10.1016/j.acvd.2017.07.003 · PMID 29133181I3
  171. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003;348(5):383-93. doi:10.1056/NEJMoa021778 · PMID 12556541D2
  172. Gaffey AE, Gathright EC, Fletcher LM, Goldstein CM. Screening for Psychological Distress and Risk of Cardiovascular Disease and Related Mortality: A SYSTEMATIZED REVIEW, META-ANALYSIS, AND CASE FOR PREVENTION. J Cardiopulm Rehabil Prev. 2022;42(6):404-415. doi:10.1097/HCR.0000000000000751 · PMID 36342683E5
  173. Galdas PM, Harrison AS, Doherty P. Gender differences in the factors predicting initial engagement at cardiac rehabilitation. Open Heart. 2018;5(1):e000764. doi:10.1136/openhrt-2017-000764 · PMID 29632680D3F2
  174. Gao L, Jiang H, Cai H, Tian J, Shi B, Qiu W, et al. Treatment With 9-mg Mazdutide for Weight Reduction in Chinese Adults With Obesity: The GLORY-2 Randomized Clinical Trial. JAMA. 2026;336(5):377-388. doi:10.1001/jama.2026.8142 · PMID 42251595I5
  175. Gao Y, Wang N, Zhang L, Liu N. Effectiveness of home-based cardiac telerehabilitation in patients with heart failure: A systematic review and meta-analysis of randomised controlled trials. J Clin Nurs. 2023;32(21-22):7661-7676. doi:10.1111/jocn.16726 · PMID 37062028F7
  176. Gapstur SM, Bouvard V, Nethan ST, Freudenheim JL, Abnet CC, English DR, et al. The IARC Perspective on Alcohol Reduction or Cessation and Cancer Risk. N Engl J Med. 2023;389(26):2486-2494. doi:10.1056/NEJMsr2306723 · PMID 38157507E4
  177. García-Campayo J, Zamorano E, Ruiz MA, Pardo A, Pérez-Páramo M, López-Gómez V, et al. Cultural adaptation into Spanish of the generalized anxiety disorder-7 (GAD-7) scale as a screening tool. Health Qual Life Outcomes. 2010;8:8. doi:10.1186/1477-7525-8-8 · PMID 20089179E5
  178. Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, et al. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023;402(10402):613-626. doi:10.1016/S0140-6736(23)01200-X · PMID 37385275E8
  179. Garvey WT, Blüher M, Osorto Contreras CK, Davies MJ, Winning Lehmann E, Pietiläinen KH, et al. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025;393(7):635-647. doi:10.1056/NEJMoa2502081 · PMID 40544433I5
  180. Gaziano JM, Brotons C, Coppolecchia R, Cricelli C, Darius H, Gorelick PB, et al. Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial. Lancet. 2018;392(10152):1036-1046. doi:10.1016/S0140-6736(18)31924-X · PMID 30158069E8I2
  181. Ge L, Sadeghirad B, Ball GDC, da Costa BR, Hitchcock CL, Svendrovski A, et al. Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials. BMJ. 2020;369:m696. doi:10.1136/bmj.m696 · PMID 32238384E3
  182. Gebremichael LG, Champion S, Nesbitt K, Pearson V, Bulamu NB, Dafny HA, et al. Effectiveness of cardiac rehabilitation programs on medication adherence in patients with cardiovascular disease: A systematic review and meta-analysis. Int J Cardiol Cardiovasc Risk Prev. 2024;20:200229. doi:10.1016/j.ijcrp.2023.200229 · PMID 38188637F5
  183. Georgiopoulos G, Katogiannis K, Mpenetou DR, Vrikos S, Delialis D, Filippatos G. Air Travel in Patients with Acute Coronary Syndromes or Heart Failure: Current Evidence, Guidance and Gaps. Eur Heart J Qual Care Clin Outcomes. 2026. doi:10.1093/ehjqcco/qcag085 · PMID 42170902E7
  184. Gerbild H, Larsen CM, Graugaard C, Areskoug Josefsson K. Physical Activity to Improve Erectile Function: A Systematic Review of Intervention Studies. Sex Med. 2018;6(2):75-89. doi:10.1016/j.esxm.2018.02.001 · PMID 29661646E7
  185. Giannuzzi P, Temporelli PL, Marchioli R, Maggioni AP, Balestroni G, Ceci V, et al. Global secondary prevention strategies to limit event recurrence after myocardial infarction: results of the GOSPEL study, a multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network. Arch Intern Med. 2008;168(20):2194-204. doi:10.1001/archinte.168.20.2194 · PMID 19001195D4I2
  186. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003;42(5):861-8. doi:10.1016/s0735-1097(03)00848-9 · PMID 12957433D5
  187. Gil-Casado C, Fernández-Vázquez U, Luna-Rojas P, Díaz-Vidal P, Diz-Ferreira E, Diz JC. Effect of preoperative prehabilitation in adults undergoing cardiac surgery on physical status and perioperative complications: a systematic review and meta-analysis. Minerva Anestesiol. 2026;92(5):458-468. doi:10.23736/S0375-9393.26.19684-9 · PMID 41954336D3
  188. Glassman AH, O'Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger JT Jr, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002;288(6):701-9. doi:10.1001/jama.288.6.701 · PMID 12169073E5I2
  189. Global Cardiovascular Risk Consortium, Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, et al. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. N Engl J Med. 2023;389(14):1273-1285. doi:10.1056/NEJMoa2206916 · PMID 37632466D2
  190. Global Cardiovascular Risk Consortium, Magnussen C, Alegre-Diaz J, Al-Nasser LA, Amouyel P, Aviles-Santa L, et al. Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. N Engl J Med. 2025;393(2):125-138. doi:10.1056/NEJMoa2415879 · PMID 40162648D2
  191. Gobeil K, White K, Bhat A, Szalai H, Lagu TC, Pack QR. Cardiac rehabilitation in Takotsubo cardiomyopathy: Predictors of utilization and effects of exercise training. Heart Lung. 2021;50(2):230-234. doi:10.1016/j.hrtlng.2020.12.006 · PMID 33340825F4
  192. Goevaerts WF, Tenbült-Van Limpt NCCW, Goossen SA, Birk MV, Liu Y, Regis M, et al. Long-term lifestyle monitoring adherence in patients after cardiac intervention: a prospective observational trial. Eur Heart J Digit Health. 2026;7(2):ztag016. doi:10.1093/ehjdh/ztag016 · PMID 41743190D4
  193. Gomes-Neto M, Durães AR, Reis HFCD, Neves VR, Martinez BP, Carvalho VO. High-intensity interval training versus moderate-intensity continuous training on exercise capacity and quality of life in patients with coronary artery disease: A systematic review and meta-analysis. Eur J Prev Cardiol. 2017;24(16):1696-1707. doi:10.1177/2047487317728370 · PMID 28825321I2
  194. Gomes-Neto M, Durães AR, Conceição LSR, Saquetto MB, Alves IG, Smart NA, et al. Effects of Different Exercise Interventions on Cardiorespiratory Fitness, as Measured by Peak Oxygen Consumption in Patients with Coronary Heart Disease: An Overview of Systematic Reviews. Sports Med. 2024;54(9):2395-2409. doi:10.1007/s40279-024-02053-w · PMID 39037575E1
  195. Gomes-Neto M, Durães AR, Conceição LSR, Silva CM, Martinez BP, Carvalho VO. High-intensity interval training versus moderate-intensity continuous training on exercise capacity and health-related quality of life in patients with coronary artery disease: An updated systematic review and meta-analysis. Braz J Phys Ther. 2025;29(1):101137. doi:10.1016/j.bjpt.2024.101137 · PMID 39644698I2
  196. Gonzalez-Jaramillo N, Wilhelm M, Arango-Rivas AM, Gonzalez-Jaramillo V, Mesa-Vieira C, Minder B, et al. Systematic Review of Physical Activity Trajectories and Mortality in Patients With Coronary Artery Disease. J Am Coll Cardiol. 2022;79(17):1690-1700. doi:10.1016/j.jacc.2022.02.036 · PMID 35483757E2
  197. Gonzalez-Viana A, Violan Fors M, Castell Abat C, Rubinat Masot M, Oliveras L, Garcia-Gil J, et al. Promoting physical activity through primary health care: the case of Catalonia. BMC Public Health. 2018;18(1):968. doi:10.1186/s12889-018-5773-2 · PMID 30075720D4
  198. González-Juanatey JR, Cordero A, Castellano JM, Masana L, Dalmau R, Ruiz E, et al. The CNIC-Polypill reduces recurrent major cardiovascular events in real-life secondary prevention patients in Spain: The NEPTUNO study. Int J Cardiol. 2022;361:116-123. doi:10.1016/j.ijcard.2022.05.015 · PMID 35569611D4E8
  199. González-Salvado V, Peña-Gil C, Lado-Baleato Ó, Cadarso-Suárez C, Prada-Ramallal G, Prescott E, et al. Offering, participation and adherence to cardiac rehabilitation programmes in the elderly: a European comparison based on the EU-CaRE multicentre observational study. Eur J Prev Cardiol. 2021;28(5):558-568. doi:10.1093/eurjpc/zwaa104 · PMID 33558875I3
  200. Gorostidi M, Sánchez-Martínez M, Ruilope LM, Graciani A, de la Cruz JJ, Santamaría R, et al. Chronic kidney disease in Spain: Prevalence and impact of accumulation of cardiovascular risk factors. Nefrologia (Engl Ed). 2018;38(6):606-615. doi:10.1016/j.nefro.2018.04.004 · PMID 29914761D6I3
  201. Goud R, de Keizer NF, ter Riet G, Wyatt JC, Hasman A, Hellemans IM, et al. Effect of guideline based computerised decision support on decision making of multidisciplinary teams: cluster randomised trial in cardiac rehabilitation. BMJ. 2009;338:b1440. doi:10.1136/bmj.b1440 · PMID 19398471F8
  202. Goyal P, Gorodeski EZ, Marcum ZA, Forman DE. Cardiac Rehabilitation to Optimize Medication Regimens in Heart Failure. Clin Geriatr Med. 2019;35(4):549-560. doi:10.1016/j.cger.2019.06.001 · PMID 31543185F5
  203. Grace SL, Russell KL, Reid RD, Oh P, Anand S, Rush J, et al. Effect of cardiac rehabilitation referral strategies on utilization rates: a prospective, controlled study. Arch Intern Med. 2011;171(3):235-41. doi:10.1001/archinternmed.2010.501 · PMID 21325114B2C1C3C4D3
  204. Graciani A, León-Muñoz LM, Guallar-Castillón P, Rodríguez-Artalejo F, Banegas JR. Cardiovascular health in a southern Mediterranean European country: a nationwide population-based study. Circ Cardiovasc Qual Outcomes. 2013;6(1):90-8. doi:10.1161/CIRCOUTCOMES.112.967893 · PMID 23300271D6I3
  205. Graham H, Prue-Owens K, Kirby J, Ramesh M. Systematic Review of Interventions Designed to Maintain or Increase Physical Activity Post-Cardiac Rehabilitation Phase II. Rehabil Process Outcome. 2020;9:1179572720941833. doi:10.1177/1179572720941833 · PMID 34497468D4
  206. Grau M, Elosua R, Cabrera de León A, Guembe MJ, Baena-Díez JM, Vega Alonso T, et al. Factores de riesgo cardiovascular en España en la primera década del siglo xxi: análisis agrupado con datos individuales de 11 estudios de base poblacional, estudio DARIOS. Rev Esp Cardiol. 2011;64(4):295-304. doi:10.1016/j.recesp.2010.11.005 · PMID 21397375D6I3
  207. Graupner C, Kimman ML, Mul S, Slok AHM, Claessens D, Kleijnen J, et al. Patient outcomes, patient experiences and process indicators associated with the routine use of patient-reported outcome measures (PROMs) in cancer care: a systematic review. Support Care Cancer. 2021;29(2):573-593. doi:10.1007/s00520-020-05695-4 · PMID 32875373E6
  208. Grave C, Gabet A, Iliou MC, Cinaud A, Tuppin P, Blacher J, et al. Temporal trends in admission for cardiac rehabilitation after an acute coronary syndrome in France from 2009 to 2021: Persistent sex, age and social disparities. Arch Cardiovasc Dis. 2024;117(4):234-243. doi:10.1016/j.acvd.2023.12.008 · PMID 38458957I3
  209. Greenberg GS, Lorenzatti D, Filtz A, Jaspan VN, Park CM, Kalich B, et al. Disparities in achieving low-density lipoprotein cholesterol goals after revascularization in a diverse real-world cohort. Eur J Prev Cardiol. 2025;32(13):1192-1201. doi:10.1093/eurjpc/zwaf235 · PMID 40238957F5
  210. Gremeaux V, Troisgros O, Benaïm S, Hannequin A, Laurent Y, Casillas JM, et al. Determining the minimal clinically important difference for the six-minute walk test and the 200-meter fast-walk test during cardiac rehabilitation program in coronary artery disease patients after acute coronary syndrome. Arch Phys Med Rehabil. 2011;92(4):611-9. doi:10.1016/j.apmr.2010.11.023 · PMID 21440707E1
  211. Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, et al. Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial. Lancet. 2011;378(9786):156-67. doi:10.1016/S0140-6736(11)60698-3 · PMID 21705063D2
  212. Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, et al. Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial. Lancet Diabetes Endocrinol. 2019;7(12):925-937. doi:10.1016/S2213-8587(19)30349-3 · PMID 31748169D2
  213. Griffo R, Tramarin R, Volterrani M, Ambrosetti M, Caiazza F, Chimini C, et al. Italian Survey on Cardiac Rehabilitation (ISYDE.13-Directory): report su strutture, organizzazione e programmi di cardiologia riabilitativa in Italia. G Ital Cardiol (Rome). 2016;17(3):217-24. doi:10.1714/2190.23666 · PMID 27029880I3
  214. Grosman-Rimon L, Hui S, Santos S, Vadasz B, Foroutan F, Farrell A, et al. Exercise rehabilitation in cardiac resynchronization: systematic review and a meta-analysis. Heart Fail Rev. 2021;26(3):507-519. doi:10.1007/s10741-020-10049-7 · PMID 33200311F4
  215. Grover S, Mishra HP, Gupta R, Gupta LK. Effect of telemonitoring and home blood pressure monitoring on blood pressure reduction in hypertensive adults: a network meta-analysis. J Hypertens. 2025;43(7):1091-1098. doi:10.1097/HJH.0000000000004008 · PMID 40156340F8
  216. Grunstein RR, Somers VK, Azarbarzin A, Malhotra A, Sands SA, Lucey BP, et al. Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea. N Engl J Med. 2026. doi:10.1056/NEJMoa2611477 · PMID 42904878I5
  217. Gu S, Du X, Wang D, Yu Y, Guo S. Effects of high intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure: A systematic review and meta-analysis. PLoS One. 2023;18(8):e0290362. doi:10.1371/journal.pone.0290362 · PMID 37590312I2
  218. Guallar-Castillón P, Gil-Montero M, León-Muñoz LM, Graciani A, Bayán-Bravo A, Taboada JM, et al. Magnitude and management of hypercholesterolemia in the adult population of Spain, 2008-2010: The ENRICA Study. Rev Esp Cardiol (Engl Ed). 2012;65(6):551-8. doi:10.1016/j.recesp.2012.02.005 · PMID 22483404D6I3
  219. Gudmundsdottir HL, Axelsson Raja A, Rossing K, Rasmusen H, Snoer M, Andersen LJ, et al. Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial. Circulation. 2025;151(2):132-144. doi:10.1161/CIRCULATIONAHA.124.070064 · PMID 39513255F4
  220. Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svärdsudd K. Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). Arch Intern Med. 2011;171(2):134-40. doi:10.1001/archinternmed.2010.510 · PMID 21263103E5I2
  221. Gungor G, Perk H, Soyupek S, Baykal B, Demir M, Sezer MT. Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: A prospective, randomized, cross-over, clinical trial. Eur J Intern Med. 2022;103:69-75. doi:10.1016/j.ejim.2022.06.013 · PMID 35752527B7
  222. Guo L, Zhang B, Xue X, Zhang X, Cai H, Jiang H, et al. Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes. Nature. 2026;652(8108):181-188. doi:10.1038/s41586-025-10031-z · PMID 41407860I5
  223. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85-94. doi:10.1093/geronj/49.2.m85 · PMID 8126356F3
  224. Gutiérrez-González E, García-Solano M, Pastor-Barriuso R, Fernández de Larrea-Baz N, Rollán-Gordo A, Peñalver-Argüeso B, et al. Socio-geographical disparities of obesity and excess weight in adults in Spain: insights from the ENE-COVID study. Front Public Health. 2023;11:1195249. doi:10.3389/fpubh.2023.1195249 · PMID 37529423D6I3
  225. Gæde P, Oellgaard J, Carstensen B, Rossing P, Lund-Andersen H, Parving HH, et al. Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial. Diabetologia. 2016;59(11):2298-2307. doi:10.1007/s00125-016-4065-6 · PMID 27531506D2
  226. Gómez González L, Supervia M, Medina-Inojosa JR, Smith JR, López Blanco ME, Miranda Vivas MT, et al. Predictors of Rehabilitation Referral Among Cardiovascular Surgical Patients. Front Cardiovasc Med. 2022;9:848610. doi:10.3389/fcvm.2022.848610 · PMID 35592404I3
  227. Górriz-Magaña J, Maruri-Sánchez R, Elorriaga A, Salterain-González N, Prieto-Lobato A, Gascueña Rubia R, et al. Patient and Physician Perspectives on Cardiovascular Risk: A Multicenter Survey of Communication Gaps Among Hospitalized Patients in Spain. Circ Cardiovasc Qual Outcomes. 2025;18(10):e011837. doi:10.1161/CIRCOUTCOMES.124.011837 · PMID 40916807D3E6
  228. Hackshaw A, Morris JK, Boniface S, Tang JL, Milenković D. Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports. BMJ. 2018;360:j5855. doi:10.1136/bmj.j5855 · PMID 29367388E4
  229. Hajek P, Phillips-Waller A, Przulj D, Pesola F, Myers Smith K, Bisal N, et al. A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. N Engl J Med. 2019;380(7):629-637. doi:10.1056/NEJMoa1808779 · PMID 30699054I2
  230. Halvorsen IP, Kristiansen M, Siersma V, Schiøtz ML, Johnsen NF, Jørgensen SMB, et al. Inequality across the cardiac rehabilitation trajectory in Denmark: investigating key sociodemographic and health-related drivers. Eur Heart J Qual Care Clin Outcomes. 2025;11(8):1474-1484. doi:10.1093/ehjqcco/qcaf114 · PMID 41006199I3
  231. Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C, Hilbrich L, et al. Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J Am Coll Cardiol. 1997;29(5):1067-73. doi:10.1016/s0735-1097(97)00015-6 · PMID 9120161D5
  232. Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C, et al. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. JAMA. 2000;283(23):3095-101. doi:10.1001/jama.283.23.3095 · PMID 10865304D5
  233. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med. 2000;342(7):454-60. doi:10.1056/NEJM200002173420702 · PMID 10675425D5
  234. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 2003;107(25):3152-8. doi:10.1161/01.CIR.0000074229.93804.5C · PMID 12810615D5
  235. Hammond-Haley M, Allen C, Han J, Patterson T, Marber M, Redwood S. Utility of wearable physical activity monitors in cardiovascular disease: a systematic review of 11 464 patients and recommendations for optimal use. Eur Heart J Digit Health. 2021;2(2):231-243. doi:10.1093/ehjdh/ztab035 · PMID 36712392E2
  236. Hannan AL, Harders MP, Hing W, Climstein M, Coombes JS, Furness J. Impact of wearable physical activity monitoring devices with exercise prescription or advice in the maintenance phase of cardiac rehabilitation: systematic review and meta-analysis. BMC Sports Sci Med Rehabil. 2019;11:14. doi:10.1186/s13102-019-0126-8 · PMID 31384474E2
  237. Hansen D, Coninx K, Dendale P. The EAPC EXPERT tool. Eur Heart J. 2017;38(30):2318-2320. doi:10.1093/eurheartj/ehx396 · PMID 28810673F8
  238. Hansen D, Dendale P, Coninx K, Vanhees L, Piepoli MF, Niebauer J, et al. The European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool: A digital training and decision support system for optimized exercise prescription in cardiovascular disease. Concept, definitions and construction methodology. Eur J Prev Cardiol. 2017;24(10):1017-1031. doi:10.1177/2047487317702042 · PMID 28420250E1
  239. Hansen D, Abreu A, Doherty P, Völler H. Dynamic strength training intensity in cardiovascular rehabilitation: is it time to reconsider clinical practice? A systematic review. Eur J Prev Cardiol. 2019;26(14):1483-1492. doi:10.1177/2047487319847003 · PMID 31046441E1
  240. Hansen D, Abreu A, Ambrosetti M, Cornelissen V, Gevaert A, Kemps H, et al. Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how: a position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2022;29(1):230-245. doi:10.1093/eurjpc/zwab007 · PMID 34077542I1
  241. Hansen D, Marinus N, Cornelissen V, Ramakers W, Coninx K. Exercise prescription by physiotherapists to patients with cardiovascular disease is in greater agreement with European recommendations after using the EXPERT training tool. Med Educ Online. 2023;28(1):2182660. doi:10.1080/10872981.2023.2182660 · PMID 36853878F8
  242. Hanssen H, Boardman H, Deiseroth A, Moholdt T, Simonenko M, Kränkel N, et al. Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Eur J Prev Cardiol. 2022;29(1):205-215. doi:10.1093/eurjpc/zwaa141 · PMID 33758927D5
  243. Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T. Nicotine replacement therapy versus control for smoking cessation. Cochrane Database Syst Rev. 2018;5(5):CD000146. doi:10.1002/14651858.CD000146.pub5 · PMID 29852054E8
  244. Hartmann-Boyce J, Livingstone-Banks J, Ordóñez-Mena JM, Fanshawe TR, Lindson N, Freeman SC, et al. Behavioural interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2021;1(1):CD013229. doi:10.1002/14651858.CD013229.pub2 · PMID 33411338I2
  245. Haykowsky M, Scott J, Esch B, Schopflocher D, Myers J, Paterson I, et al. A meta-analysis of the effects of exercise training on left ventricular remodeling following myocardial infarction: start early and go longer for greatest exercise benefits on remodeling. Trials. 2011;12:92. doi:10.1186/1745-6215-12-92 · PMID 21463531D3D5E1
  246. Haykowsky MJ, Liang Y, Pechter D, Jones LW, McAlister FA, Clark AM. A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed. J Am Coll Cardiol. 2007;49(24):2329-36. doi:10.1016/j.jacc.2007.02.055 · PMID 17572248D5
  247. He CJ, Zhu CY, Zhu YJ, Zou ZX, Wang SJ, Zhai CL, et al. Effect of exercise-based cardiac rehabilitation on clinical outcomes in patients with myocardial infarction in the absence of obstructive coronary artery disease (MINOCA). Int J Cardiol. 2020;315:9-14. doi:10.1016/j.ijcard.2020.05.019 · PMID 32416201F4
  248. Hecht HS, Cronin P, Blaha MJ, Budoff MJ, Kazerooni EA, Narula J, et al. 2016 SCCT/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans: A report of the Society of Cardiovascular Computed Tomography and Society of Thoracic Radiology. J Cardiovasc Comput Tomogr. 2017;11(1):74-84. doi:10.1016/j.jcct.2016.11.003 · PMID 27916431B7
  249. Hegewald J, Wegewitz UE, Euler U, van Dijk JL, Adams J, Fishta A, et al. Interventions to support return to work for people with coronary heart disease. Cochrane Database Syst Rev. 2019;3(3):CD010748. doi:10.1002/14651858.CD010748.pub2 · PMID 30869157E5E7
  250. Heidenreich PA, Bhatt A, Nazir NT, Schaffner W, Vardeny O. Adult Immunizations as Part of Cardiovascular Care: 2026 ACC Concise Clinical Guidance: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2026. doi:10.1016/j.jacc.2026.07.004 · PMID 42554529D1
  251. Heimer M, Schmitz S, Teschler M, Schäfer H, Douma ER, Habibovic M, et al. eHealth for maintenance cardiovascular rehabilitation: a systematic review and meta-analysis. Eur J Prev Cardiol. 2023;30(15):1634-1651. doi:10.1093/eurjpc/zwad145 · PMID 37154363D4
  252. Herrmann HC, Chang G, Klugherz BD, Mahoney PD. Hemodynamic effects of sildenafil in men with severe coronary artery disease. N Engl J Med. 2000;342(22):1622-6. doi:10.1056/NEJM200006013422201 · PMID 10833207B7E7
  253. Heymsfield SB, Aronne LJ, Montgomery P, Klickstein LB, Coleman LA, Dole K, et al. Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial. Nat Med. 2026;32(3):869-882. doi:10.1038/s41591-026-04204-0 · PMID 41772149E3I5
  254. Hodkinson A, Kontopantelis E, Adeniji C, van Marwijk H, McMillian B, Bower P, et al. Interventions Using Wearable Physical Activity Trackers Among Adults With Cardiometabolic Conditions: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(7):e2116382. doi:10.1001/jamanetworkopen.2021.16382 · PMID 34283229E2
  255. Horn DB, Ryan DH, Kis SG, Alves B, Mu Y, Kim SG, et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. Lancet. 2026;406(10522):2927-2944. doi:10.1016/S0140-6736(25)02165-8 · PMID 41275875I5
  256. Hosseinpour A, Sood A, Kamalpour J, Zandi E, Pakmehr S, Hosseinpour H, et al. Glucagon-Like Peptide-1 Receptor Agonists and Major Adverse Cardiovascular Events in Patients With and Without Diabetes: A Meta-Analysis of Randomized-Controlled Trials. Clin Cardiol. 2024;47(7):e24314. doi:10.1002/clc.24314 · PMID 38953365E3
  257. Howes S, Hartmann-Boyce J, Livingstone-Banks J, Hong B, Lindson N. Antidepressants for smoking cessation. Cochrane Database Syst Rev. 2020;4(4):CD000031. doi:10.1002/14651858.CD000031.pub5 · PMID 32319681E8
  258. Hu FB, Beleslin B, Blaha MJ, Kris-Etherton PM, Seligman HK, Williams KA Sr. Food and Health: Nutrition for Prevention and Management of Cardiovascular Disease: 2026 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol. 2026. doi:10.1016/j.jacc.2026.08.025 · PMID 42814074E3I1
  259. Hu Y, Zong G, Liu G, Wang M, Rosner B, Pan A, et al. Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality. N Engl J Med. 2018;379(7):623-632. doi:10.1056/NEJMoa1803626 · PMID 30110591D2
  260. Hughes JR, Keely J, Naud S. Shape of the relapse curve and long-term abstinence among untreated smokers. Addiction. 2004;99(1):29-38. doi:10.1111/j.1360-0443.2004.00540.x · PMID 14678060E4
  261. Hughes JW, Kuhn TA, Ede D, Gathright EC, Josephson RA. Meta-Analysis of Antidepressant Pharmacotherapy in Patients Eligible for Cardiac Rehabilitation: ANTIDEPRESSANT AMBIVALENCE. J Cardiopulm Rehabil Prev. 2022;42(6):434-441. doi:10.1097/HCR.0000000000000699 · PMID 35797521E5
  262. Hulzebos EH, Smit Y, Helders PP, van Meeteren NL. Preoperative physical therapy for elective cardiac surgery patients. Cochrane Database Syst Rev. 2012;11(11):CD010118. doi:10.1002/14651858.CD010118.pub2 · PMID 23152283D3
  263. Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618-3731. doi:10.1093/eurheartj/ehac237 · PMID 36017548F4
  264. Huxley RR, Woodward M. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet. 2011;378(9799):1297-305. doi:10.1016/S0140-6736(11)60781-2 · PMID 21839503E4
  265. Ikonomidis I, Marinou M, Vlastos D, Kourea K, Andreadou I, Liarakos N, et al. Effects of varenicline and nicotine replacement therapy on arterial elasticity, endothelial glycocalyx and oxidative stress during a 3-month smoking cessation program. Atherosclerosis. 2017;262:123-130. doi:10.1016/j.atherosclerosis.2017.05.012 · PMID 28549278D5
  266. IsHak WW, Hamilton MA, Korouri S, Diniz MA, Mirocha J, Hedrick R, et al. Comparative Effectiveness of Psychotherapy vs Antidepressants for Depression in Heart Failure: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(1):e2352094. doi:10.1001/jamanetworkopen.2023.52094 · PMID 38231511E5
  267. Ishaque S, Karnon J, Chen G, Nair R, Salter AB. A systematic review of randomised controlled trials evaluating the use of patient-reported outcome measures (PROMs). Qual Life Res. 2019;28(3):567-592. doi:10.1007/s11136-018-2016-z · PMID 30284183E6
  268. Ishibashi T, Kaneko H, Ueno K, Morita K, Itoh H, Okada A, et al. Association Between Early Initiation of Cardiac Rehabilitation and Short-Term Outcomes of Patients With Acute Heart Failure Admitted to the Intensive Care Unit. Am J Cardiol. 2023;206:285-291. doi:10.1016/j.amjcard.2023.07.070 · PMID 37717477D3
  269. Ishiguro H, Kodama S, Horikawa C, Fujihara K, Hirose AS, Hirasawa R, et al. In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Sports Med. 2016;46(1):67-77. doi:10.1007/s40279-015-0379-7 · PMID 26604100D5E1
  270. Ismail H, McFarlane JR, Dieberg G, Smart NA. Exercise training program characteristics and magnitude of change in functional capacity of heart failure patients. Int J Cardiol. 2014;171(1):62-5. doi:10.1016/j.ijcard.2013.11.045 · PMID 24326210E1
  271. Izquierdo-García J, Arranz-Escudero A, Tello de Meneses R, De la Torre N, Amat-Macías IM, Castillo Martín JI, et al. Efficacy of a cardiac rehabilitation program in a municipal sports center compared to the hospital program: randomized controlled trial eCARCEX. An Sist Sanit Navar. 2023;46(3). doi:10.23938/ASSN.1050 · PMID 37997791D4
  272. Jaarsma T, Hill L, Bayes-Genis A, La Rocca HB, Castiello T, Čelutkienė J, et al. Self-care of heart failure patients: practical management recommendations from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2021;23(1):157-174. doi:10.1002/ejhf.2008 · PMID 32945600E4E7
  273. Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038 · PMID 35658024E3E8I2
  274. Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, Wharton S, et al. Tirzepatide for Obesity Treatment and Diabetes Prevention. N Engl J Med. 2025;392(10):958-971. doi:10.1056/NEJMoa2410819 · PMID 39536238E8
  275. Jastreboff AM, Kaplan LM, Davies MJ, Wilding JPH, Ahmad NN, Murray M, et al. Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity. N Engl J Med. 2026;395(18):1781-1793. doi:10.1056/NEJMoa2604169 · PMID 42814954I5
  276. Jennings C, Kotseva K, De Bacquer D, Hoes A, de Velasco J, Brusaferro S, et al. Effectiveness of a preventive cardiology programme for high CVD risk persistent smokers: the EUROACTION PLUS varenicline trial. Eur Heart J. 2014;35(21):1411-20. doi:10.1093/eurheartj/ehu051 · PMID 24616337I2
  277. Jennings CS, Astin F, Prescott E, Hansen T, Gale Chris P, De Bacquer D. Illness perceptions and health literacy are strongly associated with health-related quality of life, anxiety, and depression in patients with coronary heart disease: results from the EUROASPIRE V cross-sectional survey. Eur J Cardiovasc Nurs. 2023;22(7):719-729. doi:10.1093/eurjcn/zvac105 · PMID 36351004E6
  278. Jensen GL, Cederholm T, Correia MITD, Gonzalez MC, Fukushima R, Pisprasert V, et al. GLIM consensus approach to diagnosis of malnutrition: A 5-year update. JPEN J Parenter Enteral Nutr. 2025;49(4):414-427. doi:10.1002/jpen.2756 · PMID 40223699E3
  279. Jetté M, Sidney K, Blümchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990;13(8):555-65. doi:10.1002/clc.4960130809 · PMID 2204507D7
  280. Ji L, Jiang H, Bi Y, Li H, Tian J, Liu D, et al. Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight. N Engl J Med. 2025;392(22):2215-2225. doi:10.1056/NEJMoa2411528 · PMID 40421736I5
  281. Jiang M, Ren X, Han L, Zheng X. Associations between sarcopenic obesity and risk of cardiovascular disease: A population-based cohort study among middle-aged and older adults using the CHARLS. Clin Nutr. 2024;43(3):796-802. doi:10.1016/j.clnu.2024.02.002 · PMID 38350287E3
  282. Johansen ND, Vaduganathan M, Bhatt AS, Lee SG, Modin D, Claggett BL, et al. Electronic nudges to increase influenza vaccination uptake in Denmark: a nationwide, pragmatic, registry-based, randomised implementation trial. Lancet. 2023;401(10382):1103-1114. doi:10.1016/S0140-6736(23)00349-5 · PMID 36889332I2
  283. Johansen ND, Modin D, Loiacono MM, Harris RC, Dufournet M, Larsen CS, et al. High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults. N Engl J Med. 2025;393(23):2291-2302. doi:10.1056/NEJMoa2509907 · PMID 40888720I2
  284. Johansen ND, Modin D, Pardo-Seco J, Rodriguez-Tenreiro-Sánchez C, Loiacono MM, Harris RC, et al. Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis. Lancet. 2025;406(10518):2425-2434. doi:10.1016/S0140-6736(25)01742-8 · PMID 41115437I2
  285. Johansen ND, Modin D, Pardo-Seco J, Rodriguez-Tenreiro-Sánchez C, Loiacono MM, Harris RC, et al. High-Dose Versus Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. Circulation. 2026;153(11):798-806. doi:10.1161/CIRCULATIONAHA.125.077801 · PMID 41212981I2
  286. Johansen ND, Modin D, Pardo-Seco J, Rodriguez-Tenreiro-Sánchez C, Loiacono MM, Harris RC, et al. High-dose vs. standard-dose influenza vaccine in heart failure: the FLUNITY-HD trial. Eur Heart J. 2026. doi:10.1093/eurheartj/ehag709 · PMID 42667303I2
  287. Johansen ND, Vaduganathan M, Bhatt AS, Modin D, Chatur S, Claggett BL, et al. Electronic Nudges to Increase Influenza Vaccination Uptake in Young and Middle-Aged Patients with Heart Failure: A Prespecified Analysis of the NUDGE-FLU-CHRONIC Trial. Circ Heart Fail. 2026. doi:10.1161/CIRCHEARTFAILURE.126.014891 · PMID 42667600I2
  288. Johansson P, Westas M, Andersson G, Alehagen U, Broström A, Jaarsma T, et al. An Internet-Based Cognitive Behavioral Therapy Program Adapted to Patients With Cardiovascular Disease and Depression: Randomized Controlled Trial. JMIR Ment Health. 2019;6(10):e14648. doi:10.2196/14648 · PMID 31584000I2
  289. Johnson HM, Gossett LK, Piper ME, Aeschlimann SE, Korcarz CE, Baker TB, et al. Effects of smoking and smoking cessation on endothelial function: 1-year outcomes from a randomized clinical trial. J Am Coll Cardiol. 2010;55(18):1988-95. doi:10.1016/j.jacc.2010.03.002 · PMID 20236788D5
  290. Jolly SS, d'Entremont MA, Lee SF, Mian R, Tyrwhitt J, Kedev S, et al. Colchicine in Acute Myocardial Infarction. N Engl J Med. 2025;392(7):633-642. doi:10.1056/NEJMoa2405922 · PMID 39555823E8I2
  291. Jones AV, Evans RA, Harrison AS, Sherar LB, Steiner MC, Doherty P, et al. Exercise rehabilitation in COPD and heart failure: comparison of two national audits. ERJ Open Res. 2022;8(4). doi:10.1183/23120541.00131-2022 · PMID 36451843F4
  292. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D, et al. Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. N Engl J Med. 2021;384(21):1981-1990. doi:10.1056/NEJMoa2102137 · PMID 33999548E8I2
  293. Jorstad HT, von Birgelen C, Alings AM, Liem A, van Dantzig JM, Jaarsma W, et al. Effect of a nurse-coordinated prevention programme on cardiovascular risk after an acute coronary syndrome: main results of the RESPONSE randomised trial. Heart. 2013;99(19):1421-30. doi:10.1136/heartjnl-2013-303989 · PMID 23813851I2
  294. Joseph AM, Norman SM, Ferry LH, Prochazka AV, Westman EC, Steele BG, et al. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med. 1996;335(24):1792-8. doi:10.1056/NEJM199612123352402 · PMID 8943160E4E8
  295. Joseph P, Roshandel G, Gao P, Pais P, Lonn E, Xavier D, et al. Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis. Lancet. 2021;398(10306):1133-1146. doi:10.1016/S0140-6736(21)01827-4 · PMID 34469765I2
  296. Kaddoura R, Al-Tamimi H, Abushanab D, Hayat S, Papasavvas T. Cardiac rehabilitation for participants with implantable cardiac devices: A systematic review and meta-analysis. Int J Cardiol Cardiovasc Risk Prev. 2024;21:200255. doi:10.1016/j.ijcrp.2024.200255 · PMID 38737437F4F6
  297. Kaihara T, Scherrenberg M, Intan-Goey V, Falter M, Kindermans H, Frederix I, et al. Efficacy of digital health interventions on depression and anxiety in patients with cardiac disease: a systematic review and meta-analysis(). Eur Heart J Digit Health. 2022;3(3):445-454. doi:10.1093/ehjdh/ztac037 · PMID 36712158E5
  298. Kamiya K, Masuda T, Tanaka S, Hamazaki N, Matsue Y, Mezzani A, et al. Quadriceps Strength as a Predictor of Mortality in Coronary Artery Disease. Am J Med. 2015;128(11):1212-9. doi:10.1016/j.amjmed.2015.06.035 · PMID 26169888D5
  299. Kanejima Y, Shimogai T, Kitamura M, Ishihara K, Izawa KP. Impact of health literacy in patients with cardiovascular diseases: A systematic review and meta-analysis. Patient Educ Couns. 2022;105(7):1793-1800. doi:10.1016/j.pec.2021.11.021 · PMID 34862114E6
  300. Kaneko H, Itoh H, Kamiya K, Morita K, Sugimoto T, Konishi M, et al. Acute-phase initiation of cardiac rehabilitation and clinical outcomes in hospitalized patients for acute heart failure. Int J Cardiol. 2021;340:36-41. doi:10.1016/j.ijcard.2021.08.041 · PMID 34454966D3F4
  301. Kang D, Choi KH, Kim H, Park H, Heo J, Park TK, et al. Prognosis after switching to electronic cigarettes following percutaneous coronary intervention: a Korean nationwide study. Eur Heart J. 2025;46(1):84-95. doi:10.1093/eurheartj/ehae705 · PMID 39429032E4
  302. Kang J, Park S, Yang HM, Shin ES, Rha SW, Bae JW, et al. Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention: 10-year follow-up of the HOST-EXAM trial. Lancet. 2026;407(10537):1439-1447. doi:10.1016/S0140-6736(26)00422-8 · PMID 41921522E8
  303. Kao CW, Chen MY, Chen TY, Lin PH. Effect of psycho-educational interventions on quality of life in patients with implantable cardioverter defibrillators: a meta-analysis of randomized controlled trials. Health Qual Life Outcomes. 2016;14(1):138. doi:10.1186/s12955-016-0543-2 · PMID 27716219E6
  304. Karam G, Agarwal A, Sadeghirad B, Jalink M, Hitchcock CL, Ge L, et al. Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis. BMJ. 2023;380:e072003. doi:10.1136/bmj-2022-072003 · PMID 36990505E3I2
  305. Karami N, Kazeminia M, Karami A, Salimi Y, Ziapour A, Janjani P. Global prevalence of depression, anxiety, and stress in cardiac patients: A systematic review and meta-analysis. J Affect Disord. 2023;324:175-189. doi:10.1016/j.jad.2022.12.055 · PMID 36584710E5
  306. Kathuria H, Soghier I, Alexander AC, Fathi JT, Fucito LM, Iaccarino JM, et al. Tobacco Treatment in the Inpatient Setting: An American College of Chest Physicians Clinical Practice Guideline. Chest. 2026. doi:10.1016/j.chest.2026.08.038 · PMID 42685897D3
  307. Kelly P, Lemmens R, Weimar C, Walsh C, Purroy F, Barber M, et al. Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomised controlled trial. Lancet. 2024;404(10448):125-133. doi:10.1016/S0140-6736(24)00968-1 · PMID 38857611E8I2
  308. Kenny E, Coyne R, McEvoy JW, McSharry J, Taylor RS, Byrne M. Behaviour change techniques and intervention characteristics in digital cardiac rehabilitation: a systematic review and meta-analysis of randomised controlled trials. Health Psychol Rev. 2024;18(1):189-228. doi:10.1080/17437199.2023.2185653 · PMID 36892523E6F8
  309. Kessels RP. Patients' memory for medical information. J R Soc Med. 2003;96(5):219-22. doi:10.1177/014107680309600504 · PMID 12724430E6
  310. Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association. Circulation. 2023;148(24):1982-2004. doi:10.1161/CIR.0000000000001191 · PMID 37947094D1
  311. Khan SS, Matsushita K, Sang Y, Ballew SH, Grams ME, Surapaneni A, et al. Development and Validation of the American Heart Association's PREVENT Equations. Circulation. 2024;149(6):430-449. doi:10.1161/CIRCULATIONAHA.123.067626 · PMID 37947085B7I1
  312. Kim JM, Stewart R, Lee YS, Lee HJ, Kim MC, Kim JW, et al. Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial. JAMA. 2018;320(4):350-358. doi:10.1001/jama.2018.9422 · PMID 30043065E5I2
  313. Kitzman DW, Whellan DJ, Duncan P, Pastva AM, Mentz RJ, Reeves GR, et al. Physical Rehabilitation for Older Patients Hospitalized for Heart Failure. N Engl J Med. 2021;385(3):203-216. doi:10.1056/NEJMoa2026141 · PMID 33999544D3F4F7I2
  314. Klein KR, Wysham C, Tuttle KR, Davies MJ, Cox D, Chen J, et al. Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial. Lancet. 2026;408(10564):1557-1570. doi:10.1016/S0140-6736(26)01865-9 · PMID 42815506I5
  315. Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA. 2002;288(3):351-7. doi:10.1001/jama.288.3.351 · PMID 12117400E7
  316. Kortebein P, Symons TB, Ferrando A, Paddon-Jones D, Ronsen O, Protas E, et al. Functional impact of 10 days of bed rest in healthy older adults. J Gerontol A Biol Sci Med Sci. 2008;63(10):1076-81. doi:10.1093/gerona/63.10.1076 · PMID 18948558D5
  317. Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, et al. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023;389(12):1069-1084. doi:10.1056/NEJMoa2306963 · PMID 37622681E8I2
  318. Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, et al. Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials. Lancet. 2024;404(10456):949-961. doi:10.1016/S0140-6736(24)01643-X · PMID 39222642E8
  319. Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, et al. Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes. N Engl J Med. 2024;390(15):1394-1407. doi:10.1056/NEJMoa2313917 · PMID 38587233E8I2
  320. Koskinas KC, Van Craenenbroeck EM, Antoniades C, Blüher M, Gorter TM, Hanssen H, et al. Obesity and cardiovascular disease: an ESC clinical consensus statement. Eur Heart J. 2024;45(38):4063-4098. doi:10.1093/eurheartj/ehae508 · PMID 39210706B7E3I1
  321. Kotseva K, Wood D, De Backer G, De Bacquer D, EUROASPIRE III Study Group. Use and effects of cardiac rehabilitation in patients with coronary heart disease: results from the EUROASPIRE III survey. Eur J Prev Cardiol. 2013;20(5):817-26. doi:10.1177/2047487312449591 · PMID 22718794I3
  322. Kotseva K, Wood D, De Bacquer D, De Backer G, Rydén L, Jennings C, et al. EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016;23(6):636-48. doi:10.1177/2047487315569401 · PMID 25687109I3
  323. Kotseva K, Wood D, De Bacquer D, EUROASPIRE investigators. Determinants of participation and risk factor control according to attendance in cardiac rehabilitation programmes in coronary patients in Europe: EUROASPIRE IV survey. Eur J Prev Cardiol. 2018;25(12):1242-1251. doi:10.1177/2047487318781359 · PMID 29873511I3
  324. Kotseva K, De Backer G, De Bacquer D, Rydén L, Hoes A, Grobbee D, et al. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry. Eur J Prev Cardiol. 2019;26(8):824-835. doi:10.1177/2047487318825350 · PMID 30739508E3F5I3
  325. Kotseva K, De Bacquer D, Jennings C, McEvoy JW, Ryden L, Ray KK, et al. Cardiac Rehabilitation in Patients with Coronary Heart Disease - Provision, Attendance, and Outcomes: Results from the INTERASPIRE Survey from Fourteen Countries Across Six WHO Regions. Glob Heart. 2025;20(1):75. doi:10.5334/gh.1458 · PMID 40917797I3
  326. Kouidi E, Hanssen H, Anding-Rost K, Cupisti A, Deligiannis A, Grupp C, et al. The role of exercise training on cardiovascular risk factors and heart disease in patients with chronic kidney disease G3-G5 and G5D: a Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the European Association of Rehabilitation in Chronic Kidney Disease. Eur J Prev Cardiol. 2024;31(12):1493-1515. doi:10.1093/eurjpc/zwae130 · PMID 38593202F4
  327. Kraal JJ, Vromen T, Spee R, Kemps HMC, Peek N. The influence of training characteristics on the effect of exercise training in patients with coronary artery disease: Systematic review and meta-regression analysis. Int J Cardiol. 2017;245:52-58. doi:10.1016/j.ijcard.2017.07.051 · PMID 28735757E1
  328. Kristensen AMD, Rossello X, Atar D, Yndigegn T, Kimura T, Latini R, et al. Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction. N Engl J Med. 2026;394(6):540-550. doi:10.1056/NEJMoa2512686 · PMID 41211954F5
  329. Krittanawong C, Isath A, Rosenson RS, Khawaja M, Wang Z, Fogg SE, et al. Alcohol Consumption and Cardiovascular Health. Am J Med. 2022;135(10):1213-1230.e3. doi:10.1016/j.amjmed.2022.04.021 · PMID 35580715E4
  330. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-13. doi:10.1046/j.1525-1497.2001.016009606.x · PMID 11556941E5
  331. Kroenke K, Spitzer RL, Williams JB, Löwe B. The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review. Gen Hosp Psychiatry. 2010;32(4):345-59. doi:10.1016/j.genhosppsych.2010.03.006 · PMID 20633738E5
  332. Kroesen SH, van Bakel BMA, de Bruin M, Pisters MF, Ortega FB, Hopman MTE, et al. A remote booster program to attenuate sedentary behaviour in patients with coronary artery disease: a randomized controlled trial. Eur J Prev Cardiol. 2026;33(12):2190-2199. doi:10.1093/eurjpc/zwaf162 · PMID 40112182D4
  333. Kronish IM, Moise N, Cheung YK, Clarke GN, Dolor RJ, Duer-Hefele J, et al. Effect of Depression Screening After Acute Coronary Syndromes on Quality of Life: The CODIACS-QoL Randomized Clinical Trial. JAMA Intern Med. 2020;180(1):45-53. doi:10.1001/jamainternmed.2019.4518 · PMID 31633746E5
  334. Kuan PX, Chan WK, Fern Ying DK, Rahman MAA, Peariasamy KM, Lai NM, et al. Efficacy of telemedicine for the management of cardiovascular disease: a systematic review and meta-analysis. Lancet Digit Health. 2022;4(9):e676-e691. doi:10.1016/S2589-7500(22)00124-8 · PMID 36028290F8
  335. Kuehnemund L, Lange SA, Feld J, Padberg JS, Fischer AJ, Makowski L, et al. Sex disparities in guideline-recommended therapies and outcomes after ST-elevation myocardial infarction in a contemporary nationwide cohort of patients over an eight-year period. Atherosclerosis. 2023;375:30-37. doi:10.1016/j.atherosclerosis.2023.05.007 · PMID 37245424F5
  336. Kurasawa Y, Maeda H, Tamaru T, Sasaki T, Matsumori K, Yokokawa Y, et al. Safety and Effectiveness of Exercise-Based Cardiac Rehabilitation for Patients With Atrial Fibrillation Following Radiofrequency Catheter Ablation Therapy: A Systematic Review and Meta-Analysis. Cureus. 2023;15(12):e50476. doi:10.7759/cureus.50476 · PMID 38094881F4
  337. Kwok CS, Hinton J, Lip GYH, Qureshi AI, Borovac JA. Deconditioning in coronary artery disease: an underrecognized problem with contemporary clinical relevance. Coron Artery Dis. 2026. doi:10.1097/MCA.0000000000001667 · PMID 42605581D5D7
  338. Køber L, Adamo M, Ruwald AC, Tomasoni D, Anderson LJ, Andersson C, et al. 2026 ESC Guidelines for the management of heart failure. Eur Heart J. 2026;47(38):5346-5457. doi:10.1093/eurheartj/ehag100 · PMID 42661420B6D1D3D4E4E5E7E8F4I1
  339. Laoutaris ID, Piotrowicz E, Kallistratos MS, Dritsas A, Dimaki N, Miliopoulos D, et al. Combined aerobic/resistance/inspiratory muscle training as the 'optimum' exercise programme for patients with chronic heart failure: ARISTOS-HF randomized clinical trial. Eur J Prev Cardiol. 2021;28(15):1626-1635. doi:10.1093/eurjpc/zwaa091 · PMID 33624071E1
  340. Lassen MCH, Johansen ND, Christensen SH, Aliabadi N, Skaarup KG, Modin D, et al. Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults: A Prespecified Analysis of the DAN-RSV Trial. JAMA. 2025;334(16):1431-1441. doi:10.1001/jama.2025.15405 · PMID 40884493I2
  341. Lassen MCH, Johansen ND, Christensen SH, Aliabadi N, Skaarup KG, Modin D, et al. RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults. N Engl J Med. 2026;394(2):138-151. doi:10.1056/NEJMoa2509810 · PMID 40888695I2
  342. Laudani C, Bujak K, Occhipinti G, Rinaldi R, Imbesi A, Sanchez JS, et al. Safety and Efficacy of Colchicine across the Spectrum of Coronary Artery Disease: A Systematic Review and Meta-Analysis of 20 Randomized Trials. Clin Pharmacol Ther. 2026;119(6):1431-1439. doi:10.1002/cpt.70246 · PMID 41760558E8
  343. le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017;389(10077):1399-1409. doi:10.1016/S0140-6736(17)30069-7 · PMID 28237263E8
  344. le Roux CW, Wharton S, Startseva E, Kloer IM, Hussain SA, Unseld A, et al. Survodutide Once Weekly for the Treatment of Adults with Obesity. N Engl J Med. 2026;395(8):776-787. doi:10.1056/NEJMoa2600751 · PMID 42253238I5
  345. Lecube A, Lecube A, Azriel S, Barreiro E, Blay G, Carretero-Gómez J, et al. The Spanish GIRO Guideline: A Paradigm Shift in the Management of Obesity in Adults. Obes Facts. 2025;18(4):375-387. doi:10.1159/000544880 · PMID 40159422E3
  346. Lee IM, Shiroma EJ, Kamada M, Bassett DR, Matthews CE, Buring JE. Association of Step Volume and Intensity With All-Cause Mortality in Older Women. JAMA Intern Med. 2019;179(8):1105-1112. doi:10.1001/jamainternmed.2019.0899 · PMID 31141585E2
  347. Lespérance F, Frasure-Smith N, Koszycki D, Laliberté MA, van Zyl LT, Baker B, et al. Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA. 2007;297(4):367-79. doi:10.1001/jama.297.4.367 · PMID 17244833E5I2
  348. Levine GN, Steinke EE, Bakaeen FG, Bozkurt B, Cheitlin MD, Conti JB, et al. Sexual activity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2012;125(8):1058-72. doi:10.1161/CIR.0b013e3182447787 · PMID 22267844E7
  349. Levine GN, Carney RM, Cohen BE, Dunn SL, Gaffey AE, Kronish IM, et al. Post-Myocardial Infarction Psychological Distress: A Scientific Statement From the American Heart Association. Circulation. 2025;152(16):e298-e310. doi:10.1161/CIR.0000000000001381 · PMID 40977387E5
  350. Li R, Wang M, Chen S, Zhang L. Comparative efficacy and adherence of telehealth cardiac rehabilitation interventions for patients with cardiovascular disease: A systematic review and network meta-analysis. Int J Nurs Stud. 2024;158:104845. doi:10.1016/j.ijnurstu.2024.104845 · PMID 39032245F8
  351. Li Y, Hruby A, Bernstein AM, Ley SH, Wang DD, Chiuve SE, et al. Saturated Fats Compared With Unsaturated Fats and Sources of Carbohydrates in Relation to Risk of Coronary Heart Disease: A Prospective Cohort Study. J Am Coll Cardiol. 2015;66(14):1538-1548. doi:10.1016/j.jacc.2015.07.055 · PMID 26429077E3
  352. Li YN, Buys N, Ferguson S, Li ZJ, Sun J. Effectiveness of cognitive behavioral therapy-based interventions on health outcomes in patients with coronary heart disease: A meta-analysis. World J Psychiatry. 2021;11(11):1147-1166. doi:10.5498/wjp.v11.i11.1147 · PMID 34888180E5
  353. Li Z, Liu Y, Wang J, Zhang C, Liu Y. Effectiveness of cognitive behavioral therapy on mood symptoms in patients with implantable cardioverter defibrillator: A systematic review and meta-analysis. Complement Ther Clin Pract. 2022;47:101570. doi:10.1016/j.ctcp.2022.101570 · PMID 35358944E5
  354. Liang Q, Wang Z, Liu J, Yan Z, Liu J, Lei M, et al. Effect of Exercise Rehabilitation in Patients With Acute Heart Failure: A Systematic Review and Meta-analysis. J Cardiovasc Nurs. 2024;39(4):390-400. doi:10.1097/JCN.0000000000001010 · PMID 37487171D3
  355. Lightwood JM, Glantz SA. Declines in acute myocardial infarction after smoke-free laws and individual risk attributable to secondhand smoke. Circulation. 2009;120(14):1373-9. doi:10.1161/CIRCULATIONAHA.109.870691 · PMID 19770392E4
  356. Lin B, Siskin M, Wang B, Natarajan S. Does exercise training improve exercise tolerance, quality of life, and echocardiographic parameters in patients with heart failure with preserved ejection fraction? A systematic review and meta-analysis of randomized controlled trials. Heart Fail Rev. 2023;28(4):795-806. doi:10.1007/s10741-022-10285-z · PMID 36334160F4
  357. Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563 · PMID 37952131D2E3E8I2I5
  358. Lindau ST, Abramsohn EM, Bueno H, D'Onofrio G, Lichtman JH, Lorenze NP, et al. Sexual activity and counseling in the first month after acute myocardial infarction among younger adults in the United States and Spain: a prospective, observational study. Circulation. 2014;130(25):2302-9. doi:10.1161/CIRCULATIONAHA.114.012709 · PMID 25512442E7
  359. Lindson N, Theodoulou A, Ordóñez-Mena JM, Fanshawe TR, Sutton AJ, Livingstone-Banks J, et al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses. Cochrane Database Syst Rev. 2023;9(9):CD015226. doi:10.1002/14651858.CD015226.pub2 · PMID 37696529E4
  360. Lindson N, Butler AR, McRobbie H, Bullen C, Hajek P, Begh R, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. 2024;1(1):CD010216. doi:10.1002/14651858.CD010216.pub8 · PMID 38189560I2
  361. Lindson N, Livingstone-Banks J, Butler AR, McRobbie H, Bullen CR, Hajek P, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. 2026;8(8):CD010216. doi:10.1002/14651858.CD010216.pub11 · PMID 42642048B7E4I2
  362. Livingstone-Banks J, Fanshawe TR, Thomas KH, Theodoulou A, Hajizadeh A, Hartman L, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023;5(5):CD006103. doi:10.1002/14651858.CD006103.pub8 · PMID 37142273E8I2
  363. Llisterri JL, Micó-Pérez RM, Velilla-Zancada S, Rodríguez-Roca GC, Prieto-Díaz MÁ, Martín-Sánchez V, et al. Prevalence of chronic kidney disease and associated factors in the Spanish population attended in primary care: Results of the IBERICAN study. Med Clin (Barc). 2021;156(4):157-165. doi:10.1016/j.medcli.2020.03.005 · PMID 32414634D6I3
  364. Llisterri-Caro JL, Cinza-Sanjurjo S, Martín-Sánchez V, Rodríguez-Roca GC, Micó-Pérez RM, Segura-Fragoso A, et al. Prevalence of Chronic Heart Failure, Associated Factors, and Therapeutic Management in Primary Care Patients in Spain, IBERICAN Study. J Clin Med. 2021;10(18). doi:10.3390/jcm10184036 · PMID 34575146I3
  365. Lloyd-Jones DM, Allen NB, Anderson CAM, Black T, Brewer LC, Foraker RE, et al. Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association. Circulation. 2022;146(5):e18-e43. doi:10.1161/CIR.0000000000001078 · PMID 35766027D5E7
  366. Lobelo F, Rohm Young D, Sallis R, Garber MD, Billinger SA, Duperly J, et al. Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association. Circulation. 2018;137(18):e495-e522. doi:10.1161/CIR.0000000000000559 · PMID 29618598E2
  367. LoConte NK, Brewster AM, Kaur JS, Merrill JK, Alberg AJ. Alcohol and Cancer: A Statement of the American Society of Clinical Oncology. J Clin Oncol. 2018;36(1):83-93. doi:10.1200/JCO.2017.76.1155 · PMID 29112463E4
  368. Loeb M, Roy A, Dokainish H, Dans A, Palileo-Villanueva LM, Karaye K, et al. Influenza vaccine to reduce adverse vascular events in patients with heart failure: a multinational randomised, double-blind, placebo-controlled trial. Lancet Glob Health. 2022;10(12):e1835-e1844. doi:10.1016/S2214-109X(22)00432-6 · PMID 36400089I2
  369. Long L, Lin CZ, Davies P, Wells V, Grace SL, Taylor RS. Interventions to promote patient utilisation of cardiac rehabilitation. Cochrane Database Syst Rev. 2026;2(2):CD007131. doi:10.1002/14651858.CD007131.pub5 · PMID 41733114D3D4
  370. Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-54. doi:10.1056/NEJMoa1212914 · PMID 23796131D2I2
  371. Look M, Dunn JP, Kushner RF, Cao D, Harris C, Gibble TH, et al. Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275 · PMID 39996356E3
  372. Lovatt S, Wong CW, Holroyd E, Butler R, Phan T, Patwala A, et al. Smoking cessation after acute coronary syndrome: A systematic review and meta-analysis. Int J Clin Pract. 2021;75(12):e14894. doi:10.1111/ijcp.14894 · PMID 34541754E4
  373. Lutz AH, Delligatti A, Allsup K, Afilalo J, Forman DE. Cardiac Rehabilitation Is Associated With Improved Physical Function in Frail Older Adults With Cardiovascular Disease. J Cardiopulm Rehabil Prev. 2020;40(5):310-318. doi:10.1097/HCR.0000000000000537 · PMID 32804797F4
  374. López-Baamonde M, Arguis MJ, Navarro-Ripoll R, Gimeno-Santos E, Romano-Andrioni B, Sisó M, et al. Multimodal Prehabilitation in Heart Transplant Recipients Improves Short-Term Post-Transplant Outcomes without Increasing Costs. J Clin Med. 2023;12(11). doi:10.3390/jcm12113724 · PMID 37297919D3F4
  375. MacEachern E, Quach J, Giacomantonio N, Theou O, Hillier T, Abel-Adegbite I, et al. Cardiac rehabilitation and frailty: a systematic review and meta-analysis. Eur J Prev Cardiol. 2024;31(16):1960-1976. doi:10.1093/eurjpc/zwae239 · PMID 39036978F4
  376. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-188. doi:10.1093/eurheartj/ehz455 · PMID 31504418B4D2
  377. Mach F, Koskinas KC, Roeters van Lennep JE, Tokgözoğlu L, Badimon L, Baigent C, et al. 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2025;46(42):4359-4378. doi:10.1093/eurheartj/ehaf190 · PMID 40878289B4B6B7C1C4D1D2I1
  378. Maddison R, Rawstorn JC, Stewart RAH, Benatar J, Whittaker R, Rolleston A, et al. Effects and costs of real-time cardiac telerehabilitation: randomised controlled non-inferiority trial. Heart. 2019;105(2):122-129. doi:10.1136/heartjnl-2018-313189 · PMID 30150328I2
  379. Magnani JW, Mujahid MS, Aronow HD, Cené CW, Dickson VV, Havranek E, et al. Health Literacy and Cardiovascular Disease: Fundamental Relevance to Primary and Secondary Prevention: A Scientific Statement From the American Heart Association. Circulation. 2018;138(2):e48-e74. doi:10.1161/CIR.0000000000000579 · PMID 29866648E6
  380. Mair JL, Salamanca-Sanabria A, Augsburger M, Frese BF, Abend S, Jakob R, et al. Effective Behavior Change Techniques in Digital Health Interventions for the Prevention or Management of Noncommunicable Diseases: An Umbrella Review. Ann Behav Med. 2023;57(10):817-835. doi:10.1093/abm/kaad041 · PMID 37625030E6
  381. Majo García R, Fernández-García D, Fernández-Martínez MN, Espinosa Villoria MG, Amaro Rodríguez L, Ruiz Cimarras MA. Prescripción de fármacos para la deshabituación tabáquica. Análisis retrospectivo del área de salud de Zamora. Aten Primaria. 2024;56(12):103049. doi:10.1016/j.aprim.2024.103049 · PMID 39047527F11
  382. Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A, et al. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. N Engl J Med. 2024;391(13):1193-1205. doi:10.1056/NEJMoa2404881 · PMID 38912654E7E8
  383. Malmstrom TK, Miller DK, Simonsick EM, Ferrucci L, Morley JE. SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle. 2016;7(1):28-36. doi:10.1002/jcsm.12048 · PMID 27066316F3
  384. Mamataz T, Ghisi GLM, Pakosh M, Grace SL. Nature, availability, and utilization of women-focused cardiac rehabilitation: a systematic review. BMC Cardiovasc Disord. 2021;21(1):459. doi:10.1186/s12872-021-02267-0 · PMID 34556036F4
  385. Mansouri ES, Queiroga F, Barbosa LM, Azevedo AK, Donaldy W, Mirbolouk MJ, et al. Tirzepatide and the Incidence of Atrial Fibrillation in Adults With Overweight or Obesity: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2026;15(18):e044249. doi:10.1161/JAHA.125.044249 · PMID 42714458I5
  386. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834-1844. doi:10.1056/NEJMoa1607141 · PMID 27633186E8
  387. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2016;375(4):311-22. doi:10.1056/NEJMoa1603827 · PMID 27295427E8I2
  388. Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, et al. 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023;44(39):4043-4140. doi:10.1093/eurheartj/ehad192 · PMID 37622663B7C4D1D2E8I1
  389. May HT, Le VT, Anderson JL, Iverson L, Bair TL, Knight S, et al. Targeted vitamin D supplementation and major adverse cardiovascular events after myocardial infarction: the TARGET-D trial. Eur Heart J. 2026. doi:10.1093/eurheartj/ehag611 · PMID 42702500E3
  390. Mazzolai L, Belch J, Venermo M, Aboyans V, Brodmann M, Bura-Rivière A, et al. Exercise therapy for chronic symptomatic peripheral artery disease. Eur Heart J. 2024;45(15):1303-1321. doi:10.1093/eurheartj/ehad734 · PMID 38461405F4
  391. Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases. Eur Heart J. 2024;45(36):3538-3700. doi:10.1093/eurheartj/ehae179 · PMID 39210722D1F4I1
  392. McDonagh ST, Dalal H, Moore S, Clark CE, Dean SG, Jolly K, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev. 2023;10(10):CD007130. doi:10.1002/14651858.CD007130.pub5 · PMID 37888805F7I2
  393. McEvoy JW, Jennings C, Kotseva K, De Bacquer D, De Backer G, Erlund I, et al. Variation in secondary prevention of coronary heart disease: the INTERASPIRE study. Eur Heart J. 2024;45(39):4184-4196. doi:10.1093/eurheartj/ehae558 · PMID 39212219I3
  394. McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912-4018. doi:10.1093/eurheartj/ehae178 · PMID 39210715B4B6B7D1D2D3D4E4E7I1
  395. McEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, et al. CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea. N Engl J Med. 2016;375(10):919-31. doi:10.1056/NEJMoa1606599 · PMID 27571048E7
  396. McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B, et al. A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise. Circulation. 2001;104(12):1350-7. PMID 11560849D5
  397. McGuire DK, Marx N, Mulvagh SL, Deanfield JE, Inzucchi SE, Pop-Busui R, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025;392(20):2001-2012. doi:10.1056/NEJMoa2501006 · PMID 40162642E8I2
  398. McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, et al. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018;379(16):1519-1528. doi:10.1056/NEJMoa1803955 · PMID 30221595E8I2
  399. McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, et al. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. N Engl J Med. 2018;379(16):1509-1518. doi:10.1056/NEJMoa1805819 · PMID 30221597E8I2
  400. McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, et al. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. N Engl J Med. 2018;379(16):1499-1508. doi:10.1056/NEJMoa1800722 · PMID 30221596E8I2
  401. Mebazaa A, Davison B, Chioncel O, Cohen-Solal A, Diaz R, Filippatos G, et al. Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial. Lancet. 2022;400(10367):1938-1952. doi:10.1016/S0140-6736(22)02076-1 · PMID 36356631F5
  402. Mediano O, González Mangado N, Montserrat JM, Alonso-Álvarez ML, Almendros I, Alonso-Fernández A, et al. International Consensus Document on Obstructive Sleep Apnea. Arch Bronconeumol. 2022;58(1):52-68. doi:10.1016/j.arbres.2021.03.017 · PMID 33875282E7
  403. Medina-Inojosa JR, Grace SL, Supervia M, Stokin G, Bonikowske AR, Thomas R, et al. Dose of Cardiac Rehabilitation to Reduce Mortality and Morbidity: A Population-Based Study. J Am Heart Assoc. 2021;10(20):e021356. doi:10.1161/JAHA.120.021356 · PMID 34612055C3D4E1F2
  404. Mendes JL, Dos Santos CM, Sousa-Pinto B. Assessment of patient-reported outcomes measures in heart failure: a systematic review. Heart Fail Rev. 2024;29(4):853-867. doi:10.1007/s10741-024-10404-y · PMID 38630207E6
  405. Meng Y, Zhuge W, Huang H, Zhang T, Ge X. The effects of early exercise on cardiac rehabilitation-related outcome in acute heart failure patients: A systematic review and meta-analysis. Int J Nurs Stud. 2022;130:104237. doi:10.1016/j.ijnurstu.2022.104237 · PMID 35421772D3F4
  406. Menéndez E, Delgado E, Fernández-Vega F, Prieto MA, Bordiú E, Calle A, et al. Prevalence, Diagnosis, Treatment, and Control of Hypertension in Spain. Results of the Di@bet.es Study. Rev Esp Cardiol (Engl Ed). 2016;69(6):572-8. doi:10.1016/j.rec.2015.11.034 · PMID 26979767D6I3
  407. Meyler SJR, Swinton PA, Bottoms L, Dalleck LC, Hunter B, Sarzynski MA, et al. Changes in Cardiorespiratory Fitness Following Exercise Training Prescribed Relative to Traditional Intensity Anchors and Physiological Thresholds: A Systematic Review with Meta-analysis of Individual Participant Data. Sports Med. 2025;55(2):301-323. doi:10.1007/s40279-024-02125-x · PMID 39538060E1
  408. Micó-Pérez RM, Hernández Segura N, Martín-Sánchez V, Barquilla-García A, Velilla-Zancada SM, Polo-García J, et al. Physical activity and metabolic syndrome in primary care patients in Spain. PLoS One. 2025;20(1):e0317593. doi:10.1371/journal.pone.0317593 · PMID 39854316I3
  409. Mikkelsen N, Cadarso-Suárez C, Lado-Baleato O, Díaz-Louzao C, Gil CP, Reeh J, et al. Improvement in VO(2peak) predicts readmissions for cardiovascular disease and mortality in patients undergoing cardiac rehabilitation. Eur J Prev Cardiol. 2020;27(8):811-819. doi:10.1177/2047487319887835 · PMID 31744334E1
  410. Milani JGPO, Milani M, Machado FVC, Wilhelm M, Marcin T, D'Ascenzi F, et al. Accurate prediction equations for ventilatory thresholds in cardiometabolic disease when gas exchange analysis is unavailable: development and validation. Eur J Prev Cardiol. 2024;31(16):1914-1924. doi:10.1093/eurjpc/zwae149 · PMID 38636093C4D7E1F3
  411. Mills EJ, Thorlund K, Eapen S, Wu P, Prochaska JJ. Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis. Circulation. 2014;129(1):28-41. doi:10.1161/CIRCULATIONAHA.113.003961 · PMID 24323793E8I2
  412. Minneboo M, Lachman S, Snaterse M, Jørstad HT, Ter Riet G, Boekholdt SM, et al. Community-Based Lifestyle Intervention in Patients With Coronary Artery Disease: The RESPONSE-2 Trial. J Am Coll Cardiol. 2017;70(3):318-327. doi:10.1016/j.jacc.2017.05.041 · PMID 28705312C3D4I2
  413. Mirzai S, Chen H, Pastva AM, Reeves GR, Mentz RJ, Kitzman DW, et al. Functional Sarcopenia and Physical Rehabilitation Response in Older Adults Hospitalized for Acute Heart Failure: A Secondary Analysis of the REHAB-HF Trial. Circ Heart Fail. 2025;18(3):e012550. doi:10.1161/CIRCHEARTFAILURE.124.012550 · PMID 39945061D3
  414. Molloy C, Long L, Mordi IR, Bridges C, Sagar VA, Davies EJ, et al. Exercise-based cardiac rehabilitation for adults with heart failure. Cochrane Database Syst Rev. 2024;3(3):CD003331. doi:10.1002/14651858.CD003331.pub6 · PMID 38451843F4I2
  415. Molloy CD, Long L, Mordi IR, Bridges C, Sagar VA, Davies EJ, et al. Exercise-based cardiac rehabilitation for adults with heart failure - 2023 Cochrane systematic review and meta-analysis. Eur J Heart Fail. 2023;25(12):2263-2273. doi:10.1002/ejhf.3046 · PMID 37850321I2
  416. Mons U, Müezzinler A, Gellert C, Schöttker B, Abnet CC, Bobak M, et al. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium. BMJ. 2015;350:h1551. doi:10.1136/bmj.h1551 · PMID 25896935E4
  417. Montero-Torreiro MF, Rey-Brandariz J, Guerra-Tort C, Candal-Pedreira C, Santiago-Pérez MI, Varela-Lema L, et al. Evolution of sedentarism prevalence in Spanish population between 1987 and 2020. Med Clin (Barc). 2024;162(6):273-279. doi:10.1016/j.medcli.2023.10.010 · PMID 37985330E2
  418. Moons P, Norekvål TM, Arbelo E, Borregaard B, Casadei B, Cosyns B, et al. Placing patient-reported outcomes at the centre of cardiovascular clinical practice: implications for quality of care and management. Eur Heart J. 2023;44(36):3405-3422. doi:10.1093/eurheartj/ehad514 · PMID 37606064E6
  419. Morris NR, Kermeen FD, Jones AW, Lee JY, Holland AE. Exercise-based rehabilitation programmes for pulmonary hypertension. Cochrane Database Syst Rev. 2023;3(3):CD011285. doi:10.1002/14651858.CD011285.pub3 · PMID 36947725F4
  420. Mostafaei H, Mori K, Hajebrahimi S, Abufaraj M, Karakiewicz PI, Shariat SF. Association of erectile dysfunction and cardiovascular disease: an umbrella review of systematic reviews and meta-analyses. BJU Int. 2021;128(1):3-11. doi:10.1111/bju.15313 · PMID 33260254E7
  421. Mounsey LA, Guo M, Lau ES, Ho JE. Exercise Training in Heart Failure: Clinical Benefits and Mechanisms. Circ Res. 2025;137(2):273-289. doi:10.1161/CIRCRESAHA.124.325533 · PMID 40608852D5
  422. Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, et al. Nutritional priorities to support GLP-1 therapy for obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society. Obes Pillars. 2025;15:100181. doi:10.1016/j.obpill.2025.100181 · PMID 40673264E3
  423. Mroué A, Roueff S, Vanorio-Vega I, Lazareth H, Kovalska O, Flahault A, et al. Benefits of Cardiac Rehabilitation in Cardio-Renal Patients With Heart Failure With Reduced Ejection Fraction. J Cardiopulm Rehabil Prev. 2023;43(6):444-452. doi:10.1097/HCR.0000000000000781 · PMID 36892848F4
  424. Mueller S, Winzer EB, Duvinage A, Gevaert AB, Edelmann F, Haller B, et al. Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA. 2021;325(6):542-551. doi:10.1001/jama.2020.26812 · PMID 33560320I2
  425. Mustafic H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, et al. Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA. 2012;307(7):713-21. doi:10.1001/jama.2012.126 · PMID 22337682E7
  426. Myers J, Beckie TM, Chastin S, Fleg JL, Kitzman DW, Thompson PD, et al. Exercise Prescriptions for Cardiovascular Health in Adults: 2026 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol. 2026. doi:10.1016/j.jacc.2026.09.008 · PMID 42878712E1I1
  427. Münzel T, Lüscher T, Kramer CM, Churchwell K, Mbakwem A, Rajagopalan S. Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A Statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation. Circulation. 2026;153(8):597-604. doi:10.1161/CIRCULATIONAHA.125.079034 · PMID 41556530E7
  428. Narumi T, Arimoto T, Funayama A, Kadowaki S, Otaki Y, Nishiyama S, et al. Prognostic importance of objective nutritional indexes in patients with chronic heart failure. J Cardiol. 2013;62(5):307-13. doi:10.1016/j.jjcc.2013.05.007 · PMID 23806549E3
  429. Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, et al. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation. 2023;148(20):1606-1635. doi:10.1161/CIR.0000000000001184 · PMID 37807924D2
  430. Ndumele CE, Rodriguez F, Dixon DL, Khan SS, Mukherjee D, Bajaj M, et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2026;87(22S):e1889-e2007. doi:10.1016/j.jacc.2026.03.056 · PMID 42265997D2E3
  431. Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, et al. Effect of Salt Substitution on Cardiovascular Events and Death. N Engl J Med. 2021;385(12):1067-1077. doi:10.1056/NEJMoa2105675 · PMID 34459569E3I2
  432. Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012;87(8):766-78. doi:10.1016/j.mayocp.2012.06.015 · PMID 22862865E7
  433. Neubeck L, Ross C, Jones J, Simpson M, Mindham R, Jaarsma T, et al. The Core Curriculum for Cardiovascular Nurses and Allied Professionals. Eur J Cardiovasc Nurs. 2023;22(7):e62-e113. doi:10.1093/eurjcn/zvad035 · PMID 37067252C3
  434. Nicholls SJ, Pavo I, Bhatt DL, Buse JB, Del Prato S, Kahn SE, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409-2420. doi:10.1056/NEJMoa2505928 · PMID 41406444E8I2
  435. Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL. Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol. 2013;61(4):404-410. doi:10.1016/j.jacc.2012.10.027 · PMID 23265346I2
  436. Nidorf SM, Fiolet ATL, Mosterd A, Eikelboom JW, Schut A, Opstal TSJ, et al. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020;383(19):1838-1847. doi:10.1056/NEJMoa2021372 · PMID 32865380E8I2
  437. Nielsen KM, Zwisler AD, Taylor RS, Svendsen JH, Lindschou J, Anderson L, et al. Exercise-based cardiac rehabilitation for adult patients with an implantable cardioverter defibrillator. Cochrane Database Syst Rev. 2019;2(2):CD011828. doi:10.1002/14651858.CD011828.pub2 · PMID 30746679F4
  438. Noda T, Kamiya K, Hamazaki N, Yamashita M, Miki T, Nozaki K, et al. Screening for sarcopenia with SARC-F in older patients hospitalized with cardiovascular disease. Eur J Cardiovasc Nurs. 2024;23(6):675-684. doi:10.1093/eurjcn/zvae017 · PMID 38315615F3
  439. Noetel M, Sanders T, Gallardo-Gómez D, Taylor P, Del Pozo Cruz B, van den Hoek D, et al. Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2024;384:e075847. doi:10.1136/bmj-2023-075847 · PMID 38355154D5
  440. Norekvål TM, Bale M, Bedane HK, Hole T, Ingul CB, Munkhaugen J. Cardiac rehabilitation participation within 6 months of discharge in 37 136 myocardial infarction survivors: a nationwide registry study. Eur J Prev Cardiol. 2024;31(16):1977-1980. doi:10.1093/eurjpc/zwad350 · PMID 37943676I3
  441. Norlund F, Wallin E, Olsson EMG, Wallert J, Burell G, von Essen L, et al. Internet-Based Cognitive Behavioral Therapy for Symptoms of Depression and Anxiety Among Patients With a Recent Myocardial Infarction: The U-CARE Heart Randomized Controlled Trial. J Med Internet Res. 2018;20(3):e88. doi:10.2196/jmir.9710 · PMID 29519777I2
  442. Nozawa Y, Nishitani-Yokoyama M, Shimada K, Kasuya H, Kunimoto M, Fujiwara K, et al. Nutritional Status in Patients Undergoing Phase II Cardiac Rehabilitation by Mini Nutritional Assessment. Cardiol Res. 2023;14(2):133-141. doi:10.14740/cr1479 · PMID 37091881E3
  443. O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1439-50. doi:10.1001/jama.2009.454 · PMID 19351941F4I2
  444. O'Connor CM, Jiang W, Kuchibhatla M, Silva SG, Cuffe MS, Callwood DD, et al. Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol. 2010;56(9):692-9. doi:10.1016/j.jacc.2010.03.068 · PMID 20723799E5I2
  445. Ofori S, Lu C, Olasupo OO, Dennis BB, Fairbairn N, Devereaux PJ, et al. Cytisine for smoking cessation: A systematic review and meta-analysis. Drug Alcohol Depend. 2023;251:110936. doi:10.1016/j.drugalcdep.2023.110936 · PMID 37678096E8
  446. Opstal TSJ, Fiolet ATL, van Broekhoven A, Mosterd A, Eikelboom JW, Nidorf SM, et al. Colchicine in Patients With Chronic Coronary Disease in Relation to Prior Acute Coronary Syndrome. J Am Coll Cardiol. 2021;78(9):859-866. doi:10.1016/j.jacc.2021.06.037 · PMID 34446156E8
  447. Orozco-Beltrán D, Brotons-Cuixart C, Banegas JR, Gil-Guillen VF, Cebrián-Cuenca AM, Martín-Rioboó E, et al. Recomendaciones preventivas vasculares. Actualización PAPPS 2024. Aten Primaria. 2024;56 Suppl 1(Suppl 1):103123. doi:10.1016/j.aprim.2024.103123 · PMID 39613355D1D2I1
  448. Oz A, Tsoumas I, Lampropoulos K, Xanthos T, Karpettas N, Papadopoulos D. Cardiac Rehabilitation After TAVI -A Systematic Review and Meta-Analysis. Curr Probl Cardiol. 2023;48(3):101531. doi:10.1016/j.cpcardiol.2022.101531 · PMID 36493915F4
  449. OʼBrien L, Wallace S, Romero L. Effect of Psychosocial and Vocational Interventions on Return-to-Work Rates Post-Acute Myocardial Infarction: A SYSTEMATIC REVIEW. J Cardiopulm Rehabil Prev. 2018;38(4):215-223. doi:10.1097/HCR.0000000000000261 · PMID 28727670E5
  450. Pack QR, Mansour M, Barboza JS, Hibner BA, Mahan MG, Ehrman JK, et al. An early appointment to outpatient cardiac rehabilitation at hospital discharge improves attendance at orientation: a randomized, single-blind, controlled trial. Circulation. 2013;127(3):349-55. doi:10.1161/CIRCULATIONAHA.112.121996 · PMID 23250992D3
  451. Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025;392(5):427-437. doi:10.1056/NEJMoa2410027 · PMID 39555826B7E8I2
  452. Pagliari C, Isernia S, Rapisarda L, Borgnis F, Lazzeroni D, Bini M, et al. Different Models of Cardiac Telerehabilitation for People with Coronary Artery Disease: Features and Effectiveness: A Systematic Review and Meta-Analysis. J Clin Med. 2024;13(12). doi:10.3390/jcm13123396 · PMID 38929925F6F7
  453. Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, et al. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. Lancet Public Health. 2022;7(3):e219-e228. doi:10.1016/S2468-2667(21)00302-9 · PMID 35247352E2
  454. Pandey A, Parashar A, Kumbhani D, Agarwal S, Garg J, Kitzman D, et al. Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circ Heart Fail. 2015;8(1):33-40. doi:10.1161/CIRCHEARTFAILURE.114.001615 · PMID 25399909D5
  455. Pandey A, Salahuddin U, Garg S, Ayers C, Kulinski J, Anand V, et al. Continuous Dose-Response Association Between Sedentary Time and Risk for Cardiovascular Disease: A Meta-analysis. JAMA Cardiol. 2016;1(5):575-83. doi:10.1001/jamacardio.2016.1567 · PMID 27434872E2
  456. Pardo-Seco J, Rodríguez-Tenreiro-Sánchez C, Giné-Vázquez I, Mallah N, Mirás-Carballal S, Piñeiro-Sotelo M, et al. High-Dose Influenza Vaccine to Reduce Hospitalizations. N Engl J Med. 2025;393(23):2303-2312. doi:10.1056/NEJMoa2509834 · PMID 40888694I2
  457. Park JJ, Doo SW, Kwon A, Kim DK, Yang WJ, Song YS, et al. Effects of Sexual Rehabilitation on Sexual Dysfunction in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis. World J Mens Health. 2023;41(2):330-341. doi:10.5534/wjmh.220124 · PMID 36593706E7
  458. Patterson R, McNamara E, Tainio M, de Sá TH, Smith AD, Sharp SJ, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Eur J Epidemiol. 2018;33(9):811-829. doi:10.1007/s10654-018-0380-1 · PMID 29589226E2
  459. Pearson MJ, Smart NA. Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis. Heart Fail Rev. 2018;23(1):91-108. doi:10.1007/s10741-017-9662-z · PMID 29185161D5D7
  460. Pedretti RFE, Iliou MC, Israel CW, Abreu A, Miljoen H, Corrà U, et al. Comprehensive multicomponent cardiac rehabilitation in cardiac implantable electronic devices recipients: a consensus document from the European Association of Preventive Cardiology (EAPC; Secondary prevention and rehabilitation section) and European Heart Rhythm Association (EHRA). Eur J Prev Cardiol. 2021;28(15):1736-1752. doi:10.1093/eurjpc/zwaa121 · PMID 34038513F4
  461. Pedretti RFE, Hansen D, Ambrosetti M, Back M, Berger T, Ferreira MC, et al. How to optimize the adherence to a guideline-directed medical therapy in the secondary prevention of cardiovascular diseases: a clinical consensus statement from the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2023;30(2):149-166. doi:10.1093/eurjpc/zwac204 · PMID 36098041F5
  462. Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S, et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021;42(1):17-96. doi:10.1093/eurheartj/ehaa605 · PMID 32860412E2I1
  463. Peral Martínez IM, Martínez Pastor A, Gomariz García JJ, Barquilla García A, Martín Sánchez V, Micó Pérez R, et al. Regional differences in the degree of glycaemic diabetes control in Spain and associated factors. IBERICAN study. Endocrinol Diabetes Nutr (Engl Ed). 2023;70(7):448-458. doi:10.1016/j.endien.2023.07.001 · PMID 37468414D6I3
  464. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, et al. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol (1985). 2001;91(2):645-53. doi:10.1152/jappl.2001.91.2.645 · PMID 11457776D5
  465. Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. N Engl J Med. 2024;391(2):109-121. doi:10.1056/NEJMoa2403347 · PMID 38785209D2E8
  466. Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. doi:10.1056/NEJMoa1411892 · PMID 26132939E8I2
  467. Piano MR, Marcus GM, Aycock DM, Buckman J, Hwang CL, Larsson SC, et al. Alcohol Use and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2025;152(1):e7-e21. doi:10.1161/CIR.0000000000001341 · PMID 40485439E4
  468. Piepoli M, Weidinger F, Aboyans V, Abreu A, Andersen ZJ, Baneras J, et al. Environmental risk factors and cardiovascular health. Eur Heart J. 2026;47(27):3474-3498. doi:10.1093/eurheartj/ehag270 · PMID 42095252E7
  469. Piepoli MF, Conraads V, Corrà U, Dickstein K, Francis DP, Jaarsma T, et al. Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation. Eur J Heart Fail. 2011;13(4):347-57. doi:10.1093/eurjhf/hfr017 · PMID 21436360B3F6
  470. Piotrowicz E, Pencina MJ, Opolski G, Zareba W, Banach M, Kowalik I, et al. Effects of a 9-Week Hybrid Comprehensive Telerehabilitation Program on Long-term Outcomes in Patients With Heart Failure: The Telerehabilitation in Heart Failure Patients (TELEREH-HF) Randomized Clinical Trial. JAMA Cardiol. 2020;5(3):300-308. doi:10.1001/jamacardio.2019.5006 · PMID 31734701I2
  471. Pizzi C, Rutjes AW, Costa GM, Fontana F, Mezzetti A, Manzoli L. Meta-analysis of selective serotonin reuptake inhibitors in patients with depression and coronary heart disease. Am J Cardiol. 2011;107(7):972-9. doi:10.1016/j.amjcard.2010.11.017 · PMID 21256471E5
  472. Piñeiro D, González-Juanatey JR, Abreu A, Alvarez EG, Ponte-Negretti C, Weisser B, et al. The Polypill (Acetyl Salicylic Acid, Atorvastatin, and Ramipril) Paradigm Shift in Secondary Prevention: Global Expert Delphi Consensus. Glob Heart. 2025;20(1):83. doi:10.5334/gh.1466 · PMID 41019772E8
  473. Platz E, Kaplan LM, le Roux CW, Wharton S, Burger S, Hussain SA, et al. Survodutide for the Treatment of Obesity: Baseline Characteristics of the SYNCHRONIZE Cardiovascular Outcomes Trial. JACC Heart Fail. 2026;14(5):102780. doi:10.1016/j.jchf.2025.102780 · PMID 41329105I5
  474. Pleym K, Dammen T, Wedon-Fekjaer H, Husebye E, Sverre E, Tonstad S, et al. A multi-component intervention increased access to smoking cessation treatment after hospitalization for atherosclerotic cardiovascular disease: a randomized trial. Eur Heart J Open. 2024;4(2):oeae028. doi:10.1093/ehjopen/oeae028 · PMID 38666249E4
  475. Pluta S, Piotrowicz E, Piotrowicz R, Lewicka E, Zaręba W, Kozieł M, et al. Remote Monitoring of Cardiac Implantable Electronic Devices in Patients Undergoing Hybrid Comprehensive Telerehabilitation in Comparison to the Usual Care. Subanalysis from Telerehabilitation in Heart Failure Patients (TELEREH-HF) Randomised Clinical Trial. J Clin Med. 2020;9(11). doi:10.3390/jcm9113729 · PMID 33233613F7
  476. Popovici M, Ursoniu S, Feier H, Mocan M, Tomulescu OMG, Kundnani NR, et al. Benefits of Using Smartphones and Other Digital Methods in Achieving Better Cardiac Rehabilitation Goals: A Systematic Review and Meta-Analysis. Med Sci Monit. 2023;29:e939132. doi:10.12659/MSM.939132 · PMID 37143317F7F8
  477. Portela BM, Shan RM, Miriyapalli L, Pasupuleti V, Diaz-Arocutipa C, Hernandez AV. Efficacy and harms of polypills for cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials. Eur J Intern Med. 2026;147:106775. doi:10.1016/j.ejim.2026.106775 · PMID 41720660E8
  478. Prieto-Díaz MA, Pallares-Carratala V, Manuel Micó-Pérez R, Escobar-Cervantes C, Martín-Sanchez V, Coca A, et al. Clinical characteristics, treatment, and blood pressure control in patients with hypertension seen by primary care physicians in Spain: the IBERICAN study. Front Cardiovasc Med. 2023;10:1295174. doi:10.3389/fcvm.2023.1295174 · PMID 38173815D6I3
  479. Psotka MA, Abraham WT, Fiuzat M, Filippatos G, Lindenfeld J, Ahmad T, et al. Functional and Symptomatic Clinical Trial Endpoints: The HFC-ARC Scientific Expert Panel. JACC Heart Fail. 2022;10(12):889-901. doi:10.1016/j.jchf.2022.09.012 · PMID 36456063E1
  480. Pujalte MF, Richart-Martínez M, Perpiñá-Galvañ J. Analysis of the status of cardiac rehabilitation in Spain: an exploratory review. An Sist Sanit Navar. 2022;45(1). doi:10.23938/ASSN.0991 · PMID 35043786D6I3
  481. Pérez-Rodrigo C, Hervás Bárbara G, Gianzo Citores M, Aranceta-Bartrina J. Prevalence of obesity and associated cardiovascular risk factors in the Spanish population: the ENPE study. Rev Esp Cardiol (Engl Ed). 2022;75(3):232-241. doi:10.1016/j.rec.2020.12.020 · PMID 33773941I3
  482. Rahman AA, He N, Rej S, Platt RW, Renoux C. Concomitant Use of Selective Serotonin Reuptake Inhibitors and Oral Anticoagulants and Risk of Major Bleeding: A Systematic Review and Meta-analysis. Thromb Haemost. 2023;123(1):54-63. doi:10.1055/a-1932-8976 · PMID 36037829E5
  483. Rajagopalan S, Brauer M, Bhatnagar A, Bhatt DL, Brook JR, Huang W, et al. Personal-Level Protective Actions Against Particulate Matter Air Pollution Exposure: A Scientific Statement From the American Heart Association. Circulation. 2020;142(23):e411-e431. doi:10.1161/CIR.0000000000000931 · PMID 33150789E7
  484. Ramachandran HJ, Jiang Y, Tam WWS, Yeo TJ, Wang W. Effectiveness of home-based cardiac telerehabilitation as an alternative to Phase 2 cardiac rehabilitation of coronary heart disease: a systematic review and meta-analysis. Eur J Prev Cardiol. 2022;29(7):1017-1043. doi:10.1093/eurjpc/zwab106 · PMID 34254118F7I2
  485. Rao A, Zecchin R, Newton PJ, Phillips JL, DiGiacomo M, Denniss AR, et al. The prevalence and impact of depression and anxiety in cardiac rehabilitation: A longitudinal cohort study. Eur J Prev Cardiol. 2020;27(5):478-489. doi:10.1177/2047487319871716 · PMID 31597473E5
  486. Ray KK, Haq I, Bilitou A, Manu MC, Burden A, Aguiar C, et al. Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study. Lancet Reg Health Eur. 2023;29:100624. doi:10.1016/j.lanepe.2023.100624 · PMID 37090089F5
  487. Rea F, Ronco R, Pedretti RFE, Merlino L, Corrao G. Better adherence with out-of-hospital healthcare improved long-term prognosis of acute coronary syndromes: Evidence from an Italian real-world investigation. Int J Cardiol. 2020;318:14-20. doi:10.1016/j.ijcard.2020.06.017 · PMID 32593725I3
  488. Recchia F, Leung CK, Yu AP, Leung W, Yu DJ, Fong DY, et al. Dose-response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med. 2023;57(16):1035-1041. doi:10.1136/bjsports-2022-106304 · PMID 36669870D5
  489. Redfern J, Thomas RJ, Briffa T, Mbau L, Gallagher R, Candelaria D, et al. World Heart Federation Roadmap on cardiac rehabilitation: a pathway to lifelong cardiovascular health. Nat Rev Cardiol. 2026. doi:10.1038/s41569-026-01312-9 · PMID 42443501D4I1
  490. Reed JL, Harris JM, Midence L, Yee EB, Grace SL. Evaluating the Heart Wise Exercise™ program: a model for safe community exercise programming. BMC Public Health. 2016;16:190. doi:10.1186/s12889-016-2866-7 · PMID 26922240D4
  491. Rey J, Pérez-Ríos M, Santiago-Pérez MI, Galán I, Schiaffino A, Varela-Lema L, et al. Smoking-attributable mortality in the autonomous communities of Spain, 2017. Rev Esp Cardiol (Engl Ed). 2022;75(2):150-158. doi:10.1016/j.rec.2020.10.023 · PMID 33685853D6
  492. Ribeiro GS, Melo RD, Deresz LF, Dal Lago P, Pontes MR, Karsten M. Cardiac rehabilitation programme after transcatheter aortic valve implantation versus surgical aortic valve replacement: Systematic review and meta-analysis. Eur J Prev Cardiol. 2017;24(7):688-697. doi:10.1177/2047487316686442 · PMID 28071146F4
  493. Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P, et al. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev. 2017;4(4):CD002902. doi:10.1002/14651858.CD002902.pub4 · PMID 28452408E5I2
  494. Riemann D, Espie CA, Altena E, Arnardottir ES, Baglioni C, Bassetti CLA, et al. The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. J Sleep Res. 2023;32(6):e14035. doi:10.1111/jsr.14035 · PMID 38016484E7
  495. Rigotti NA, Thorndike AN, Regan S, McKool K, Pasternak RC, Chang Y, et al. Bupropion for smokers hospitalized with acute cardiovascular disease. Am J Med. 2006;119(12):1080-7. doi:10.1016/j.amjmed.2006.04.024 · PMID 17145253E8
  496. Rigotti NA, Pipe AL, Benowitz NL, Arteaga C, Garza D, Tonstad S. Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial. Circulation. 2010;121(2):221-9. doi:10.1161/CIRCULATIONAHA.109.869008 · PMID 20048210E4E8I2
  497. Rigotti NA, Benowitz NL, Prochaska J, Leischow S, Nides M, Blumenstein B, et al. Cytisinicline for Smoking Cessation: A Randomized Clinical Trial. JAMA. 2023;330(2):152-160. doi:10.1001/jama.2023.10042 · PMID 37432430E8I2I5
  498. Rigotti NA, Benowitz NL, Prochaska JJ, Cain DF, Ball J, Clarke A, et al. Cytisinicline for Vaping Cessation in Adults Using Nicotine E-Cigarettes: The ORCA-V1 Randomized Clinical Trial. JAMA Intern Med. 2024;184(8):922-930. doi:10.1001/jamainternmed.2024.1313 · PMID 38709500B7I5
  499. Rigotti NA, Benowitz NL, Prochaska JJ, Rubinstein M, Clarke A, Blumenstein B, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025;185(6):648-655. doi:10.1001/jamainternmed.2025.0628 · PMID 40257755E4E8I2I5
  500. Riley DL, Krepostman S, Stewart DE, Suskin N, Arthur HM, Grace SL. A mixed methods study of continuity of care from cardiac rehabilitation to primary care physicians. Can J Cardiol. 2009;25(6):e187-92. doi:10.1016/s0828-282x(09)70096-0 · PMID 19536388D4
  501. Risom SS, Zwisler AD, Sibilitz KL, Rasmussen TB, Taylor RS, Thygesen LC, et al. Cardiac Rehabilitation for Patients Treated for Atrial Fibrillation With Ablation Has Long-Term Effects: 12-and 24-Month Follow-up Results From the Randomized CopenHeart(RFA) Trial. Arch Phys Med Rehabil. 2020;101(11):1877-1886. doi:10.1016/j.apmr.2020.06.026 · PMID 32750373F4
  502. Rivera A, Campos B, Ceolin S, Godoi A, Castanha E, Campello Jorge CA, et al. Polypill-based strategy vs. usual care for secondary prevention of cardiovascular disease: a meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2023;30(16):1828-1837. doi:10.1093/eurjpc/zwad245 · PMID 37490769E8
  503. Roberts A, Benterud E, Santana MJ, Engbers J, Lorenz C, Verdin N, et al. APPROACH e-PROM system: a user-centered development and evaluation of an electronic patient-reported outcomes measurement system for management of coronary artery disease. J Patient Rep Outcomes. 2024;8(1):102. doi:10.1186/s41687-024-00779-9 · PMID 39196484E6
  504. Rochester CL, Alison JA, Carlin B, Jenkins AR, Cox NS, Bauldoff G, et al. Pulmonary Rehabilitation for Adults with Chronic Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2023;208(4):e7-e26. doi:10.1164/rccm.202306-1066ST · PMID 37581410F4
  505. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489-95. doi:10.1503/cmaj.050051 · PMID 16129869F3
  506. Rockwood K, Theou O. Using the Clinical Frailty Scale in Allocating Scarce Health Care Resources. Can Geriatr J. 2020;23(3):210-215. doi:10.5770/cgj.23.463 · PMID 32904824F3
  507. Roerecke M, Kaczorowski J, Tobe SW, Gmel G, Hasan OSM, Rehm J. The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis. Lancet Public Health. 2017;2(2):e108-e120. doi:10.1016/S2468-2667(17)30003-8 · PMID 29253389E4
  508. Rojo-Martínez G, Valdés S, Soriguer F, Vendrell J, Urrutia I, Pérez V, et al. Incidence of diabetes mellitus in Spain as results of the nation-wide cohort Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo. study. Sci Rep. 2020;10(1):2765. doi:10.1038/s41598-020-59643-7 · PMID 32066839D6I3
  509. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35(5):526-9. doi:10.1093/ageing/afl041 · PMID 16757522F3
  510. Roshandel G, Khoshnia M, Poustchi H, Hemming K, Kamangar F, Gharavi A, et al. Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial. Lancet. 2019;394(10199):672-683. doi:10.1016/S0140-6736(19)31791-X · PMID 31448738I2
  511. Rossello X, Prescott EIB, Kristensen AMD, Latini R, Fuster V, Fagerland MW, et al. β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials. Lancet. 2025;406(10508):1128-1137. doi:10.1016/S0140-6736(25)01592-2 · PMID 40897190F5
  512. Rossello X, Dominguez-Rodriguez A, Latini R, Sánchez PL, Raposeiras-Roubín S, Anguita M, et al. Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial. Eur Heart J. 2026;47(6):701-715. doi:10.1093/eurheartj/ehaf673 · PMID 40884211F5
  513. Ruano-Ravina A, Pena-Gil C, Abu-Assi E, Raposeiras S, van 't Hof A, Meindersma E, et al. Participation and adherence to cardiac rehabilitation programs. A systematic review. Int J Cardiol. 2016;223:436-443. doi:10.1016/j.ijcard.2016.08.120 · PMID 27557484I3
  514. Rubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jensen C, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224 · PMID 33755728E8
  515. Rubino DM, Greenway FL, Khalid U, O'Neil PM, Rosenstock J, Sørrig R, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150. doi:10.1001/jama.2021.23619 · PMID 35015037E8
  516. Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-262. doi:10.1016/S2213-8587(24)00316-4 · PMID 39824205B7E3
  517. Ruivo J, Moholdt T, Abreu A. Overview of Cardiac Rehabilitation following post-acute myocardial infarction in European Society of Cardiology member countries. Eur J Prev Cardiol. 2023;30(9):758-768. doi:10.1093/eurjpc/zwad024 · PMID 36722203D6I3
  518. Rábade-Castedo C, de Granda-Orive JI, Riesco-Miranda JA, De Higes-Martínez E, Ramos-Pinedo Á, Cabrera-César E, et al. Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023. Arch Bronconeumol. 2023;59(10):651-661. doi:10.1016/j.arbres.2023.07.024 · PMID 37567792E4E8
  519. Rørth R, Wong C, Kragholm K, Fosbøl EL, Mogensen UM, Lamberts M, et al. Return to the Workforce After First Hospitalization for Heart Failure: A Danish Nationwide Cohort Study. Circulation. 2016;134(14):999-1009. doi:10.1161/CIRCULATIONAHA.116.021859 · PMID 27507406B7E7
  520. Rørth R, Fosbøl EL, Mogensen UM, Kragholm K, Numé AK, Gislason GH, et al. Employment status at time of first hospitalization for heart failure is associated with a higher risk of death and rehospitalization for heart failure. Eur J Heart Fail. 2018;20(2):240-247. doi:10.1002/ejhf.1046 · PMID 29148231E7
  521. Saberi S, Wheeler M, Bragg-Gresham J, Hornsby W, Agarwal PP, Attili A, et al. Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial. JAMA. 2017;317(13):1349-1357. doi:10.1001/jama.2017.2503 · PMID 28306757F4
  522. Sadeghi M, Rahiminam H, Amerizadeh A, Masoumi G, Heidari R, Shahabi J, et al. Prevalence of Return to Work in Cardiovascular Patients After Cardiac Rehabilitation: A Systematic Review and Meta-analysis. Curr Probl Cardiol. 2022;47(7):100876. doi:10.1016/j.cpcardiol.2021.100876 · PMID 34034921E7
  523. Sadeghi M, Askari A, Bostan F, Heidari A, Rafiee H, Alavi Tabatabaei G, et al. Impact of cardiac rehabilitation on erectile dysfunction in cardiovascular patients: a systematic review and meta-analysis. Sex Med. 2024;12(3):qfae043. doi:10.1093/sexmed/qfae043 · PMID 38953013E7
  524. Salguero-Bodes R, Arribas-Ynsaurriaga F. Ten years of the RECALCAR registry: reflections on cardiovascular care in Spain. Rev Esp Cardiol (Engl Ed). 2023;76(7):500-502. doi:10.1016/j.rec.2023.01.015 · PMID 37019206I3
  525. Sandberg A, Ravn-Fischer A, Johnsson A, Lachonius M, Bäck M. Evaluation of a digital patient education programme in patients with coronary artery disease, a survey-based study. BMC Health Serv Res. 2024;24(1):1012. doi:10.1186/s12913-024-11374-5 · PMID 39223603E6
  526. Santaularia N, Arnau A, Torà N, Ramírez-Morros A, Vázquez-Oliva G, CarPE3 Study Investigators. Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial. J Cardiopulm Rehabil Prev. 2026;46(2):115-124. doi:10.1097/HCR.0000000000000993 · PMID 41529161D4
  527. Santiago de Araújo Pio C, Chaves GS, Davies P, Taylor RS, Grace SL. Interventions to promote patient utilisation of cardiac rehabilitation. Cochrane Database Syst Rev. 2019;2(2):CD007131. doi:10.1002/14651858.CD007131.pub4 · PMID 30706942F8
  528. Scherrenberg M, Falter M, Abreu A, Aktaa S, Busnatu S, Casado-Arroyo R, et al. Standards for cardiac telerehabilitation. Eur Heart J. 2025;46(38):3714-3737. doi:10.1093/eurheartj/ehaf408 · PMID 40742158F7F8F9I1
  529. Schwalm JD, McCready T, Lopez-Jaramillo P, Yusoff K, Attaran A, Lamelas P, et al. A community-based comprehensive intervention to reduce cardiovascular risk in hypertension (HOPE 4): a cluster-randomised controlled trial. Lancet. 2019;394(10205):1231-1242. doi:10.1016/S0140-6736(19)31949-X · PMID 31488369I2
  530. SCORE2 working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439-2454. doi:10.1093/eurheartj/ehab309 · PMID 34120177D1
  531. SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration. SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe. Eur Heart J. 2023;44(28):2544-2556. doi:10.1093/eurheartj/ehad260 · PMID 37247330D1
  532. SCORE2-OP working group and ESC Cardiovascular risk collaboration. SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions. Eur Heart J. 2021;42(25):2455-2467. doi:10.1093/eurheartj/ehab312 · PMID 34120185D1
  533. Scott-Sheldon LAJ, Gathright EC, Donahue ML, Balletto B, Feulner MM, DeCosta J, et al. Mindfulness-Based Interventions for Adults with Cardiovascular Disease: A Systematic Review and Meta-Analysis. Ann Behav Med. 2020;54(1):67-73. doi:10.1093/abm/kaz020 · PMID 31167026E5
  534. Semnani-Azad Z, Khan TA, Chiavaroli L, Chen V, Bhatt HA, Chen A, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389:e082007. doi:10.1136/bmj-2024-082007 · PMID 40533200E3
  535. Shah AS, Langrish JP, Nair H, McAllister DA, Hunter AL, Donaldson K, et al. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet. 2013;382(9897):1039-48. doi:10.1016/S0140-6736(13)60898-3 · PMID 23849322E7
  536. Shah AS, Lee KK, McAllister DA, Hunter A, Nair H, Whiteley W, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis. BMJ. 2015;350:h1295. doi:10.1136/bmj.h1295 · PMID 25810496E7
  537. Sharp RP, Gales BJ. Nebivolol versus other beta blockers in patients with hypertension and erectile dysfunction. Ther Adv Urol. 2017;9(2):59-63. doi:10.1177/1756287216685027 · PMID 28203288B7
  538. Shi W, Ghisi GLM, Zhang L, Hyun K, Pakosh M, Gallagher R. A systematic review, meta-analysis, and meta-regression of patient education for secondary prevention in patients with coronary heart disease: impact on psychological outcomes. Eur J Cardiovasc Nurs. 2022;21(7):643-654. doi:10.1093/eurjcn/zvac001 · PMID 35134883E6
  539. Shi W, Ghisi GLM, Zhang L, Hyun K, Pakosh M, Gallagher R. Systematic review, meta-analysis and meta-regression to determine the effects of patient education on health behaviour change in adults diagnosed with coronary heart disease. J Clin Nurs. 2023;32(15-16):5300-5327. doi:10.1111/jocn.16519 · PMID 36088570C3E6
  540. Shi W, Green H, Sikhosana N, Fernandez R. Effectiveness of Telehealth Cardiac Rehabilitation Programs on Health Outcomes of Patients With Coronary Heart Diseases: An Umbrella Review. J Cardiopulm Rehabil Prev. 2024;44(1):15-25. doi:10.1097/HCR.0000000000000807 · PMID 37335820F8
  541. Shields GE, Wells A, Doherty P, Heagerty A, Buck D, Davies LM. Cost-effectiveness of cardiac rehabilitation: a systematic review. Heart. 2018;104(17):1403-1410. doi:10.1136/heartjnl-2017-312809 · PMID 29654096F9
  542. Shirley M. Mazdutide: First Approval. Drugs. 2025;85(12):1621-1627. doi:10.1007/s40265-025-02249-y · PMID 41028652I5
  543. Shrestha N, Kukkonen-Harjula KT, Verbeek JH, Ijaz S, Hermans V, Pedisic Z. Workplace interventions for reducing sitting at work. Cochrane Database Syst Rev. 2018;12(12):CD010912. doi:10.1002/14651858.CD010912.pub5 · PMID 30556590E2
  544. Sibilitz KL, Tang LH, Berg SK, Thygesen LC, Risom SS, Rasmussen TB, et al. Long-term effects of cardiac rehabilitation after heart valve surgery - results from the randomised CopenHeart(VR) trial. Scand Cardiovasc J. 2022;56(1):247-255. doi:10.1080/14017431.2022.2095432 · PMID 35811477F4
  545. Silva CC, Presseau J, van Allen Z, Schenk PM, Moreto M, Dinsmore J, et al. Effectiveness of Interventions for Changing More Than One Behavior at a Time to Manage Chronic Conditions: A Systematic Review and Meta-analysis. Ann Behav Med. 2024;58(6):432-444. doi:10.1093/abm/kaae021 · PMID 38721982E6
  546. Silveira C, Abreu A. Cardiac rehabilitation in Portugal: Results from the 2013-14 national survey. Rev Port Cardiol. 2016;35(12):659-668. doi:10.1016/j.repc.2016.06.006 · PMID 27865682I3
  547. Silvestri A, Galetta P, Cerquetani E, Marazzi G, Patrizi R, Fini M, et al. Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. Eur Heart J. 2003;24(21):1928-32. doi:10.1016/j.ehj.2003.08.016 · PMID 14585251E7
  548. Simonenko M, Hansen D, Niebauer J, Volterrani M, Adamopoulos S, Amarelli C, et al. Prevention and rehabilitation after heart transplantation: A clinical consensus statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a section of ESOT. Eur J Prev Cardiol. 2024;31(11):1385-1399. doi:10.1093/eurjpc/zwae179 · PMID 38894688F4
  549. Skaarup KG, Lassen MCH, Yafasov M, Pareek M, Christensen SH, Johansen ND, et al. RSV vaccine for preventing respiratory and cardiovascular hospitalizations in heart failure: a prespecified analysis of the extended DAN-RSV trial. Eur J Heart Fail. 2026. doi:10.1093/ejhf/xuag282 · PMID 42702887I2
  550. Ski CF, Taylor RS, McGuigan K, Long L, Lambert JD, Richards SH, et al. Psychological interventions for depression and anxiety in patients with coronary heart disease, heart failure or atrial fibrillation. Cochrane Database Syst Rev. 2024;4(4):CD013508. doi:10.1002/14651858.CD013508.pub3 · PMID 38577875E5I2
  551. Smart NA, Downes D, van der Touw T, Hada S, Dieberg G, Pearson MJ, et al. The Effect of Exercise Training on Blood Lipids: A Systematic Review and Meta-analysis. Sports Med. 2025;55(1):67-78. doi:10.1007/s40279-024-02115-z · PMID 39331324D5E1
  552. Smedegaard L, Numé AK, Charlot M, Kragholm K, Gislason G, Hansen PR. Return to Work and Risk of Subsequent Detachment From Employment After Myocardial Infarction: Insights From Danish Nationwide Registries. J Am Heart Assoc. 2017;6(10). doi:10.1161/JAHA.117.006486 · PMID 28978528E7
  553. Snoek JA, Prescott EI, van der Velde AE, Eijsvogels TMH, Mikkelsen N, Prins LF, et al. Effectiveness of Home-Based Mobile Guided Cardiac Rehabilitation as Alternative Strategy for Nonparticipation in Clinic-Based Cardiac Rehabilitation Among Elderly Patients in Europe: A Randomized Clinical Trial. JAMA Cardiol. 2021;6(4):463-468. doi:10.1001/jamacardio.2020.5218 · PMID 33112363I2
  554. Solera AR, Supervia M, Medina Inojosa JR, Senon DB, Lopez-Jimenez F, Grace SL. Impact of vaccination education in cardiac rehabilitation on attitudes and knowledge. PLOS Glob Public Health. 2024;4(3):e0002610. doi:10.1371/journal.pgph.0002610 · PMID 38457378E6
  555. Soriguer F, Goday A, Bosch-Comas A, Bordiú E, Calle-Pascual A, Carmena R, et al. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia. 2012;55(1):88-93. doi:10.1007/s00125-011-2336-9 · PMID 21987347D6I3
  556. Sotirakos S, Fouda B, Mohamed Razif NA, Cribben N, Mulhall C, O'Byrne A, et al. Harnessing artificial intelligence in cardiac rehabilitation, a systematic review. Future Cardiol. 2022;18(2):154-164. doi:10.2217/fca-2021-0010 · PMID 33860679F8
  557. Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092-7. doi:10.1001/archinte.166.10.1092 · PMID 16717171E5
  558. St-Onge MP, Aggarwal B, Fernandez-Mendoza J, Johnson D, Kline CE, Knutson KL, et al. Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health: A Scientific Statement From the American Heart Association. Circ Cardiovasc Qual Outcomes. 2025;18(5):e000139. doi:10.1161/HCQ.0000000000000139 · PMID 40223596E7
  559. Stacey D, Lewis KB, Smith M, Carley M, Volk R, Douglas EE, et al. Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev. 2024;1(1):CD001431. doi:10.1002/14651858.CD001431.pub6 · PMID 38284415F8
  560. Stead LF, Koilpillai P, Fanshawe TR, Lancaster T. Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database Syst Rev. 2016;3(3):CD008286. doi:10.1002/14651858.CD008286.pub3 · PMID 27009521E4
  561. Stefanakis M, Batalik L, Antoniou V, Pepera G. Safety of home-based cardiac rehabilitation: A systematic review. Heart Lung. 2022;55:117-126. doi:10.1016/j.hrtlng.2022.04.016 · PMID 35533492F6
  562. Steinke EE, Jaarsma T, Barnason SA, Byrne M, Doherty S, Dougherty CM, et al. Sexual counselling for individuals with cardiovascular disease and their partners: a consensus document from the American Heart Association and the ESC Council on Cardiovascular Nursing and Allied Professions (CCNAP). Eur Heart J. 2013;34(41):3217-35. doi:10.1093/eurheartj/eht270 · PMID 23900695E7
  563. Steinmetz C, Heinemann S, Kutschka I, Hasenfuß G, Asendorf T, Remppis BA, et al. Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial. Trials. 2023;24(1):533. doi:10.1186/s13063-023-07511-w · PMID 37582774D3
  564. Stens NA, Bakker EA, Mañas A, Buffart LM, Ortega FB, Lee DC, et al. Relationship of Daily Step Counts to All-Cause Mortality and Cardiovascular Events. J Am Coll Cardiol. 2023;82(15):1483-1494. doi:10.1016/j.jacc.2023.07.029 · PMID 37676198E2
  565. Stergiou GS, Avolio AP, Palatini P, Kyriakoulis KG, Schutte AE, Mieke S, et al. European Society of Hypertension recommendations for the validation of cuffless blood pressure measuring devices: European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability. J Hypertens. 2023;41(12):2074-2087. doi:10.1097/HJH.0000000000003483 · PMID 37303198F8
  566. Streck JM, Rigotti NA, Livingstone-Banks J, Tindle HA, Clair C, Munafò MR, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024;5(5):CD001837. doi:10.1002/14651858.CD001837.pub4 · PMID 38770804D3
  567. Suematsu Y, Minei A, Sumita Y, Kanaoka K, Nakai M, Miyamoto Y, et al. Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction. Eur J Prev Cardiol. 2026;33(6):917-928. doi:10.1093/eurjpc/zwaf705 · PMID 41642116D3
  568. Suissa K, Larivière J, Eisenberg MJ, Eberg M, Gore GC, Grad R, et al. Efficacy and Safety of Smoking Cessation Interventions in Patients With Cardiovascular Disease: A Network Meta-Analysis of Randomized Controlled Trials. Circ Cardiovasc Qual Outcomes. 2017;10(1). doi:10.1161/CIRCOUTCOMES.115.002458 · PMID 28093398E4E8I2
  569. Sun W, Gholizadeh L, Perry L, Kang K, Heydari M. Factors associated with return to work following myocardial infarction: A systematic review of observational studies. J Clin Nurs. 2021;30(3-4):323-340. doi:10.1111/jocn.15562 · PMID 33179345E7
  570. Sweda R, Siontis GCM, Nikolakopoulou A, Windecker S, Pilgrim T. Antidepressant treatment in patients following acute coronary syndromes: a systematic review and Bayesian meta-analysis. ESC Heart Fail. 2020;7(6):3610-3620. doi:10.1002/ehf2.12861 · PMID 32935927E5
  571. Swift DL, Ross LM, Laddu DR, Conroy MB, German CA, Evangelista LS, et al. Role of Physical Activity in Obesity Treatment and Cardiometabolic Health: A Scientific Statement From the American Heart Association. Circulation. 2026;154(1):e1-e16. doi:10.1161/CIR.0000000000001441 · PMID 42220241E2
  572. Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, Abad J, Duran-Cantolla J, Cabriada V, et al. Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial. Lancet Respir Med. 2020;8(4):359-367. doi:10.1016/S2213-2600(19)30271-1 · PMID 31839558E7
  573. Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, Sánchez-de-la-Torre A, Moncusí-Moix A, Torres G, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. JAMA. 2023;330(13):1255-1265. doi:10.1001/jama.2023.17465 · PMID 37787793E7
  574. Tainio M, de Nazelle AJ, Götschi T, Kahlmeier S, Rojas-Rueda D, Nieuwenhuijsen MJ, et al. Can air pollution negate the health benefits of cycling and walking? Prev Med. 2016;87:233-236. doi:10.1016/j.ypmed.2016.02.002 · PMID 27156248E7
  575. Talevski J, Wong Shee A, Rasmussen B, Kemp G, Beauchamp A. Teach-back: A systematic review of implementation and impacts. PLoS One. 2020;15(4):e0231350. doi:10.1371/journal.pone.0231350 · PMID 32287296E6
  576. Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388 · PMID 31733140E8I2
  577. Taylor G, McNeill A, Girling A, Farley A, Lindson-Hawley N, Aveyard P. Change in mental health after smoking cessation: systematic review and meta-analysis. BMJ. 2014;348:g1151. doi:10.1136/bmj.g1151 · PMID 24524926E4
  578. Taylor JL, Holland DJ, Spathis JG, Beetham KS, Wisløff U, Keating SE, et al. Guidelines for the delivery and monitoring of high intensity interval training in clinical populations. Prog Cardiovasc Dis. 2019;62(2):140-146. doi:10.1016/j.pcad.2019.01.004 · PMID 30685470E1
  579. Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, et al. Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis. J Am Coll Cardiol. 2019;73(12):1430-1443. doi:10.1016/j.jacc.2018.12.072 · PMID 30922474F4I2
  580. Tedesco E, Ceccato S, Torazzi A, Santin L, Losso L, Bottardi A, et al. Cytisine for smoking cessation in hospitalised smokers with cardiovascular diseases: an observational study. Intern Emerg Med. 2025;20(3):817-828. doi:10.1007/s11739-025-03888-5 · PMID 39939444E8
  581. Tegegne TK, Rawstorn JC, Nourse RA, Kibret KT, Ahmed KY, Maddison R. Effects of exercise-based cardiac rehabilitation delivery modes on exercise capacity and health-related quality of life in heart failure: a systematic review and network meta-analysis. Open Heart. 2022;9(1). doi:10.1136/openhrt-2021-001949 · PMID 35680170B2F7I2
  582. Terada T, Pap R, Thomas A, Wei R, Noda T, Visintini S, et al. Effects of muscle strength training combined with aerobic training versus aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease: a systematic review and meta-analysis of randomised clinical trials. Br J Sports Med. 2024;58(20):1225-1234. doi:10.1136/bjsports-2024-108530 · PMID 39214675D5E1
  583. Theodoulou A, Chepkin SC, Ye W, Fanshawe TR, Bullen C, Hartmann-Boyce J, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023;6(6):CD013308. doi:10.1002/14651858.CD013308.pub2 · PMID 37335995E8
  584. Thom S, Poulter N, Field J, Patel A, Prabhakaran D, Stanton A, et al. Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial. JAMA. 2013;310(9):918-29. doi:10.1001/jama.2013.277064 · PMID 24002278D4I2
  585. Thomas RJ, Balady G, Banka G, Beckie TM, Chiu J, Gokak S, et al. 2018 ACC/AHA Clinical Performance and Quality Measures for Cardiac Rehabilitation: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am Coll Cardiol. 2018;71(16):1814-1837. doi:10.1016/j.jacc.2018.01.004 · PMID 29606402F9
  586. Thombs BD, Ziegelstein RC, Whooley MA. Optimizing detection of major depression among patients with coronary artery disease using the patient health questionnaire: data from the heart and soul study. J Gen Intern Med. 2008;23(12):2014-7. doi:10.1007/s11606-008-0802-y · PMID 18815842E5
  587. Thompson S, Wiebe N, Arena R, Rouleau C, Aggarwal S, Wilton SB, et al. Effectiveness and Utilization of Cardiac Rehabilitation Among People With CKD. Kidney Int Rep. 2021;6(6):1537-1547. doi:10.1016/j.ekir.2021.03.889 · PMID 34169194F4
  588. Thosar SS, Bielko SL, Mather KJ, Johnston JD, Wallace JP. Effect of prolonged sitting and breaks in sitting time on endothelial function. Med Sci Sports Exerc. 2015;47(4):843-9. doi:10.1249/MSS.0000000000000479 · PMID 25137367E2
  589. Tonet E, Raisi A, Zagnoni S, Chiaranda G, Pasanisi G, Aschieri D, et al. Multidomain Rehabilitation for Older Patients with Myocardial Infarction. N Engl J Med. 2025;393(10):973-982. doi:10.1056/NEJMoa2502799 · PMID 40879431D4F4
  590. Tong DC, Quinn S, Nasis A, Hiew C, Roberts-Thomson P, Adams H, et al. Colchicine in Patients With Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial. Circulation. 2020;142(20):1890-1900. doi:10.1161/CIRCULATIONAHA.120.050771 · PMID 32862667E8I2
  591. Tonstad S, Farsang C, Klaene G, Lewis K, Manolis A, Perruchoud AP, et al. Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre, randomised study. Eur Heart J. 2003;24(10):946-55. doi:10.1016/s0195-668x(03)00003-4 · PMID 12714026E4E8
  592. Topolski TD, LoGerfo J, Patrick DL, Williams B, Walwick J, Patrick MB. The Rapid Assessment of Physical Activity (RAPA) among older adults. Prev Chronic Dis. 2006;3(4):A118. PMID 16978493B7E2
  593. Toval A, Bakker EA, Granada-Maia JB, Núñez de Arenas-Arroyo S, Solis-Urra P, Eijsvogels TMH, et al. Exercise type and settings, quality of life, and mental health in coronary artery disease: a network meta-analysis. Eur Heart J. 2025;46(23):2186-2201. doi:10.1093/eurheartj/ehae870 · PMID 39809303F7I2
  594. Tremblay MS, Aubert S, Barnes JD, Saunders TJ, Carson V, Latimer-Cheung AE, et al. Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act. 2017;14(1):75. doi:10.1186/s12966-017-0525-8 · PMID 28599680E2
  595. Tucker B, Tucker WJ, Chung JS, Figtree GA, Keech A, Patel S. The efficacy and safety of low dose colchicine in atherosclerotic cardiovascular disease: a systematic review and meta-analysis. Eur J Prev Cardiol. 2026;33(5):694-704. doi:10.1093/eurjpc/zwaf302 · PMID 40378184E8
  596. Tudor-Locke C, Han H, Aguiar EJ, Barreira TV, Schuna JM Jr, Kang M, et al. How fast is fast enough? Walking cadence (steps/min) as a practical estimate of intensity in adults: a narrative review. Br J Sports Med. 2018;52(12):776-788. doi:10.1136/bjsports-2017-097628 · PMID 29858465E2
  597. Turk-Adawi K, Supervia M, Lopez-Jimenez F, Pesah E, Ding R, Britto RR, et al. Cardiac Rehabilitation Availability and Density around the Globe. EClinicalMedicine. 2019;13:31-45. doi:10.1016/j.eclinm.2019.06.007 · PMID 31517261D6I3
  598. Ueki K, Sasako T, Okazaki Y, Kato M, Okahata S, Katsuyama H, et al. Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2017;5(12):951-964. doi:10.1016/S2213-8587(17)30327-3 · PMID 29079252D2
  599. Umpierre D, Ribeiro PA, Schaan BD, Ribeiro JP. Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis. Diabetologia. 2013;56(2):242-51. doi:10.1007/s00125-012-2774-z · PMID 23160642D5
  600. US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Chelmow D, et al. Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2022;327(16):1577-1584. doi:10.1001/jama.2022.4983 · PMID 35471505E8
  601. Valgimigli M, Choi KH, Giacoppo D, Gragnano F, Kimura T, Watanabe H, et al. Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis. Lancet. 2025;406(10508):1091-1102. doi:10.1016/S0140-6736(25)01562-4 · PMID 40902613E8
  602. Van Damme A, McDermott S, McMurtry S, Kung JY, Gyenes G, Norris C. Secondary Prevention and Rehabilitation for Spontaneous Coronary Artery Dissection: A Systematic Review. Can J Cardiol. 2023;39(11S):S395-S411. doi:10.1016/j.cjca.2023.08.013 · PMID 37604409F4
  603. van den Berg MJ, van der Graaf Y, Deckers JW, de Kanter W, Algra A, Kappelle LJ, et al. Smoking cessation and risk of recurrent cardiovascular events and mortality after a first manifestation of arterial disease. Am Heart J. 2019;213:112-122. doi:10.1016/j.ahj.2019.03.019 · PMID 31132583E4
  604. Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3314-3414. doi:10.1093/eurheartj/ehae176 · PMID 39210723E4E7F4
  605. van Veldhuisen SL, Gorter TM, van Woerden G, de Boer RA, Rienstra M, Hazebroek EJ, et al. Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis. Eur Heart J. 2022;43(20):1955-1969. doi:10.1093/eurheartj/ehac071 · PMID 35243488E3
  606. Vardeny O, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, et al. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial. JAMA. 2021;325(1):39-49. doi:10.1001/jama.2020.23649 · PMID 33275134I2
  607. Vetrovsky T, Siranec M, Frybova T, Gant I, Svobodova I, Linhart A, et al. Lifestyle Walking Intervention for Patients With Heart Failure With Reduced Ejection Fraction: The WATCHFUL Trial. Circulation. 2024;149(3):177-188. doi:10.1161/CIRCULATIONAHA.123.067395 · PMID 37955615E2
  608. Viamonte SG, Joaquim AV, Alves AJ, Vilela E, Capela A, Ferreira C, et al. Cardio-Oncology Rehabilitation for Cancer Survivors With High Cardiovascular Risk: A Randomized Clinical Trial. JAMA Cardiol. 2023;8(12):1119-1128. doi:10.1001/jamacardio.2023.3558 · PMID 37819656F4
  609. Vigorito C, Abreu A, Ambrosetti M, Belardinelli R, Corrà U, Cupples M, et al. Frailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section. Eur J Prev Cardiol. 2017;24(6):577-590. doi:10.1177/2047487316682579 · PMID 27940954F3
  610. Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-3337. doi:10.1093/eurheartj/ehab484 · PMID 34458905B4B7C1C4D1D2E2E3E4E5E7E8I1
  611. Vitale C, Berthelot E, Coats AJS, Loreena H, Albert NM, Tkaczyszyn M, et al. Assessment of frailty in patients with heart failure: A new Heart Failure Frailty Score developed by Delphi consensus. ESC Heart Fail. 2025;12(3):1818-1831. doi:10.1002/ehf2.15187 · PMID 39904922F3
  612. Volkert D, Beck AM, Cederholm T, Cruz-Jentoft A, Hooper L, Kiesswetter E, et al. ESPEN practical guideline: Clinical nutrition and hydration in geriatrics. Clin Nutr. 2022;41(4):958-989. doi:10.1016/j.clnu.2022.01.024 · PMID 35306388E3
  613. Vonk T, Maessen MFH, Hopman MTE, Snoek JA, Aengevaeren VL, Franklin BA, et al. Temporal Trends in Cardiac Rehabilitation Participation and Its Core Components: A Nationwide Cohort Study From the Netherlands. J Cardiopulm Rehabil Prev. 2024;44(3):180-186. doi:10.1097/HCR.0000000000000858 · PMID 38373064I3
  614. Voskoboinik A, Kalman JM, De Silva A, Nicholls T, Costello B, Nanayakkara S, et al. Alcohol Abstinence in Drinkers with Atrial Fibrillation. N Engl J Med. 2020;382(1):20-28. doi:10.1056/NEJMoa1817591 · PMID 31893513E4
  615. Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-3537. doi:10.1093/eurheartj/ehae177 · PMID 39210710B4B6C1D1D2D3D4E7E8F4I1
  616. Vromen T, Peek NB, Abu-Hanna A, Kornaat M, Kemps HM. A computerized decision support system did not improve personalization of exercise-based cardiac rehabilitation according to latest recommendations. Eur J Prev Cardiol. 2021;28(5):572-580. doi:10.1093/eurjpc/zwaa066 · PMID 33624044F8
  617. Vámosi M, Lauberg A, Borregaard B, Christensen AV, Thrysoee L, Rasmussen TB, et al. Patient-reported outcomes predict high readmission rates among patients with cardiac diagnoses. Findings from the DenHeart study. Int J Cardiol. 2020;300:268-275. doi:10.1016/j.ijcard.2019.09.046 · PMID 31748184E6
  618. Walker N, Howe C, Glover M, McRobbie H, Barnes J, Nosa V, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014;371(25):2353-62. doi:10.1056/NEJMoa1407764 · PMID 25517706E8I2
  619. Walker N, Smith B, Barnes J, Verbiest M, Parag V, Pokhrel S, et al. Cytisine versus varenicline for smoking cessation in New Zealand indigenous Māori: a randomized controlled trial. Addiction. 2021;116(10):2847-2858. doi:10.1111/add.15489 · PMID 33761149E8
  620. Wallert J, Olsson EM, Pingel R, Norlund F, Leosdottir M, Burell G, et al. Attending Heart School and long-term outcome after myocardial infarction: A decennial SWEDEHEART registry study. Eur J Prev Cardiol. 2020;27(2):145-154. doi:10.1177/2047487319871714 · PMID 31514507E6
  621. Wang C, Bangdiwala SI, Rangarajan S, Lear SA, AlHabib KF, Mohan V, et al. Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries. Eur Heart J. 2019;40(20):1620-1629. doi:10.1093/eurheartj/ehy695 · PMID 30517670E7
  622. Wang S, Gao L, Wang C, Bai J, Shen M, Zhao X, et al. Effects of internet-based cognitive behavioral therapy on anxiety and depressive symptoms among patients with cardiovascular and cerebrovascular diseases: a systematic review and meta-analysis. Front Psychiatry. 2024;15:1433558. doi:10.3389/fpsyt.2024.1433558 · PMID 39886052E5
  623. Wang Y, Wu Y, Wei S, Lu S, Zhao J, Zhang Y, et al. Effectiveness of exercise-based cardiac rehabilitation for patients with left ventricular assist device: A systematic review and meta-analysis. Perfusion. 2025;40(2):317-327. doi:10.1177/02676591241245876 · PMID 38587932F4
  624. West R, Zatonski W, Cedzynska M, Lewandowska D, Pazik J, Aveyard P, et al. Placebo-controlled trial of cytisine for smoking cessation. N Engl J Med. 2011;365(13):1193-200. doi:10.1056/NEJMoa1102035 · PMID 21991893E8I2
  625. West RR, Jones DA, Henderson AH. Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction. Heart. 2012;98(8):637-44. doi:10.1136/heartjnl-2011-300302 · PMID 22194152I2
  626. Wewege MA, Ahn D, Yu J, Liou K, Keech A. High-Intensity Interval Training for Patients With Cardiovascular Disease-Is It Safe? A Systematic Review. J Am Heart Assoc. 2018;7(21):e009305. doi:10.1161/JAHA.118.009305 · PMID 30376749B7F6
  627. Wharton S, Aronne LJ, Stefanski A, Alfaris NF, Ciudin A, Yokote K, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med. 2025;393(18):1796-1806. doi:10.1056/NEJMoa2511774 · PMID 40960239B7I5
  628. Wharton S, Freitas P, Hjelmesæth J, Kabisch M, Kandler K, Lingvay I, et al. Once-weekly semaglutide 7·2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial. Lancet Diabetes Endocrinol. 2025;13(11):949-963. doi:10.1016/S2213-8587(25)00226-8 · PMID 40961952E8
  629. Wharton S, le Roux CW, Startseva E, Kloer IM, Alhussein A, Hussain SA, et al. Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes. N Engl J Med. 2026. doi:10.1056/NEJMoa2607219 · PMID 42820639I5
  630. WHO CVD Risk Chart Working Group. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. Lancet Glob Health. 2019;7(10):e1332-e1345. doi:10.1016/S2214-109X(19)30318-3 · PMID 31488387B7
  631. Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med. 1997;12(7):439-45. doi:10.1046/j.1525-1497.1997.00076.x · PMID 9229283E5
  632. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. doi:10.1056/NEJMoa2032183 · PMID 33567185E8I2
  633. Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553-1564. doi:10.1111/dom.14725 · PMID 35441470E8
  634. Wilhelm M, Abreu A, Adami PE, Ambrosetti M, Antonopoulou M, Biffi A, et al. EAPC Core Curriculum for Preventive Cardiology. Eur J Prev Cardiol. 2022;29(1):251-274. doi:10.1093/eurjpc/zwab017 · PMID 33791783C3C4
  635. Williams CA, Wadey C, Pieles G, Stuart G, Taylor RS, Long L. Physical activity interventions for people with congenital heart disease. Cochrane Database Syst Rev. 2020;10(10):CD013400. doi:10.1002/14651858.CD013400.pub2 · PMID 33112424F4
  636. Windle SB, Dehghani P, Roy N, Old W, Grondin FR, Bata I, et al. Smoking abstinence 1 year after acute coronary syndrome: follow-up from a randomized controlled trial of varenicline in patients admitted to hospital. CMAJ. 2018;190(12):E347-E354. doi:10.1503/cmaj.170377 · PMID 29581161D3E4E8
  637. Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115(24):3086-94. doi:10.1161/CIRCULATIONAHA.106.675041 · PMID 17548726I2
  638. Wium-Andersen MK, Wium-Andersen IK, Prescott EIB, Overvad K, Jørgensen MB, Osler M. An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression: a cohort and meta-analytic approach. Br J Psychiatry. 2020;217(2):434-441. doi:10.1192/bjp.2019.130 · PMID 31179963E5
  639. Wong CX, Cheung CC, Montenegro G, Oo HH, Peña IJ, Tang JJ, et al. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial. JAMA. 2026;335(4):317-325. doi:10.1001/jama.2025.21056 · PMID 41206802E3
  640. Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, et al. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. Lancet. 2018;391(10129):1513-1523. doi:10.1016/S0140-6736(18)30134-X · PMID 29676281E4
  641. Wood DA, Kotseva K, Connolly S, Jennings C, Mead A, Jones J, et al. Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlled trial. Lancet. 2008;371(9629):1999-2012. doi:10.1016/S0140-6736(08)60868-5 · PMID 18555911C3I2
  642. Wood DA, Jennings CS, Kotseva K, Adamska A, Erlund I, Ganly S, et al. ESC Guidelines on prevention and rehabilitation in coronary heart disease and current practice: the EUROASPIRE VI survey. Eur Heart J. 2026. doi:10.1093/eurheartj/ehag741 · PMID 42666091C1D4D6I3
  643. Woolf KJ, Zabad MN, Post JM, McNitt S, Williams GC, Bisognano JD. Effect of nicotine replacement therapy on cardiovascular outcomes after acute coronary syndromes. Am J Cardiol. 2012;110(7):968-70. doi:10.1016/j.amjcard.2012.05.028 · PMID 22727182E8
  644. Wu CM, McKeon J, Abbott JD, Jiang L, Wu WC. Referral to Cardiac Rehabilitation and Outcomes for Patients With Takotsubo Cardiomyopathy. J Cardiopulm Rehabil Prev. 2019;39(3):E8-E11. doi:10.1097/HCR.0000000000000433 · PMID 31022006F4
  645. Wu G, Hu Y, Ding K, Li X, Li J, Shang Z. The Effect of Cardiac Rehabilitation on Lipid Levels in Patients with Coronary Heart Disease. A Systematic Review and Meta-Analysis. Glob Heart. 2022;17(1):83. doi:10.5334/gh.1170 · PMID 36578919F5
  646. Wu L, Li J, Zheng Y, Xue M, Yan W, Sun Y, et al. Early Cardiac Rehabilitation for Critically Ill Patients With Acute Decompensated Heart Failure: A Randomized Clinical Trial. JAMA Netw Open. 2025;8(7):e2524141. doi:10.1001/jamanetworkopen.2025.24141 · PMID 40736732D3
  647. Wu Y, Levis B, Sun Y, He C, Krishnan A, Neupane D, et al. Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis. BMJ. 2021;373:n972. doi:10.1136/bmj.n972 · PMID 33972268E5
  648. Wu Y, Lin J, Gong B, Wang L, Ruan Z, Xu K. Cardiac Rehabilitation in Atrial Fibrillation Patients With Left Atrial Appendage Occlusion: A RANDOMIZED TRIAL. J Cardiopulm Rehabil Prev. 2022;42(4):266-271. doi:10.1097/HCR.0000000000000693 · PMID 35428035F4
  649. Xu C, Jia J, Zhao B, Yuan M, Luo N, Zhang F, et al. Objectively measured daily steps and health outcomes: an umbrella review of the systematic review and meta-analysis of observational studies. BMJ Open. 2024;14(10):e088524. doi:10.1136/bmjopen-2024-088524 · PMID 39384238E2
  650. Xu L, Li F, Zhou C, Li J, Hong C, Tong Q. The effect of mobile applications for improving adherence in cardiac rehabilitation: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2019;19(1):166. doi:10.1186/s12872-019-1149-5 · PMID 31299903F8
  651. Yoon SJ, Jung JG, Lee S, Kim JS, Ahn SK, Shin ES, et al. The protective effect of alcohol consumption on the incidence of cardiovascular diseases: is it real? A systematic review and meta-analysis of studies conducted in community settings. BMC Public Health. 2020;20(1):90. doi:10.1186/s12889-019-7820-z · PMID 31964375E4
  652. Yuan C, Zhou T, Cui X, Xie S, Lu X, Liu F. Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study. Eur J Prev Cardiol. 2026;33(12):2274-2283. doi:10.1093/eurjpc/zwag054 · PMID 41603771E2
  653. Yubero-Serrano EM, Fernandez-Gandara C, Garcia-Rios A, Rangel-Zuñiga OA, Gutierrez-Mariscal FM, Torres-Peña JD, et al. Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial. PLoS Med. 2020;17(9):e1003282. doi:10.1371/journal.pmed.1003282 · PMID 32903262D5
  654. Yusuf S, Joseph P, Dans A, Gao P, Teo K, Xavier D, et al. Polypill with or without Aspirin in Persons without Cardiovascular Disease. N Engl J Med. 2021;384(3):216-228. doi:10.1056/NEJMoa2028220 · PMID 33186492E8I2
  655. Zeng Z, Shen Y, Wan L, Yang X, Hu Q, Luo H, et al. Kinesiophobia in patients after cardiac surgery: a scoping review. BMC Cardiovasc Disord. 2024;24(1):469. doi:10.1186/s12872-024-04140-2 · PMID 39223455E5
  656. Zeymer U, Goss F, Kunadt M, Oldenburg S, Hochadel M, Thiele H, et al. Patient knowledge about risk factors, achievement of target values, and guideline-adherent secondary prevention therapies 12 months after acute myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2024;13(7):537-545. doi:10.1093/ehjacc/zuae066 · PMID 38768234D3
  657. Zhang Y, Zhou J, Chen X, Huang H, Fan Z, Wang Z. Optimal type and dose of exercise to improve glycated haemoglobin in individuals with type 1 diabetes: A systematic review and Bayesian dose-response network meta-analysis of RCTs. Diabetes Obes Metab. 2025;27(12):7146-7157. doi:10.1111/dom.70115 · PMID 40919668E1
  658. Zheng J, Xiao T, Mendes M, Wang S. Exercise Training for Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review and Bayesian Network Meta-Analysis. ESC Heart Fail. 2026. doi:10.1093/eschf/xvag237 · PMID 42740707F4
  659. Zheng SL, Roddick AJ. Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis. JAMA. 2019;321(3):277-287. doi:10.1001/jama.2018.20578 · PMID 30667501I2
  660. Zhu S, Sinha D, Kirk M, Michalopoulou M, Hajizadeh A, Wren G, et al. Effectiveness of behavioural interventions with motivational interviewing on physical activity outcomes in adults: systematic review and meta-analysis. BMJ. 2024;386:e078713. doi:10.1136/bmj-2023-078713 · PMID 38986547E2
  661. Ziapour A, Kazeminia M, Rouzbahani M, Bakhshi S, Montazeri N, Yıldırım M, et al. Global prevalence of sexual dysfunction in cardiovascular patients: a systematic review and meta-analysis. Syst Rev. 2024;13(1):136. doi:10.1186/s13643-024-02525-0 · PMID 38769586E7
  662. Zou H, Cao X, Chair SY. A systematic review and meta-analysis of mindfulness-based interventions for patients with coronary heart disease. J Adv Nurs. 2021;77(5):2197-2213. doi:10.1111/jan.14738 · PMID 33433036E5
  663. Zullo MD, Dolansky MA, Josephson RA, Cheruvu VK. Older Adult Attendance in Cardiac Rehabilitation: IMPACT OF FUNCTIONAL STATUS AND POSTACUTE CARE AFTER ACUTE MYOCARDIAL INFARCTION IN 63 092 MEDICARE BENEFICIARIES. J Cardiopulm Rehabil Prev. 2018;38(1):17-23. doi:10.1097/HCR.0000000000000264 · PMID 28671934F4
  664. Íñiguez Romo A, Bertomeu Martínez V, Rodríguez Padial L, Anguita Sánchez M, Ruiz Mateas F, Hidalgo Urbano R, et al. The RECALCAR Project. Healthcare in the Cardiology Units of the Spanish National Health System, 2011 to 2014. Rev Esp Cardiol (Engl Ed). 2017;70(7):567-575. doi:10.1016/j.rec.2017.03.022 · PMID 28457812I3
  665. Ögmundsdottir Michelsen H, Sjölin I, Schlyter M, Hagström E, Kiessling A, Henriksson P, et al. Cardiac rehabilitation after acute myocardial infarction in Sweden - evaluation of programme characteristics and adherence to European guidelines: The Perfect Cardiac Rehabilitation (Perfect-CR) study. Eur J Prev Cardiol. 2020;27(1):18-27. doi:10.1177/2047487319865729 · PMID 31349776I3

Otros documentos con DOI (5)

  1. Arrarte Esteban V, Campuzano Ruiz R, De Pablo Zarzosa C, Fernández Olmo MR. Situación de la rehabilitación cardiaca en España. Resultados del registro AULARC. Revista Española de Cardiología. 2024;77(9):796-798. doi:10.1016/j.recesp.2024.04.011F9
  2. Castro Conde A, Gorgojo Martínez JJ, Manito Lorite N. Actualización del posicionamiento sobre obesidad y enfermedad cardiovascular y renal de las Asociaciones de Cardiología Preventiva, Cardiología Clínica e Insuficiencia Cardiaca de la SEC. REC: CardioClinics. 2025;60(2):158-160. doi:10.1016/j.rccl.2024.11.004I1
  3. L.J. Visseren F, Mach F, M. Smulders Y, Carballo D, C. Koskinas K, Bäck M, et al. Guía ESC 2021 sobre la prevención de la enfermedad cardiovascular en la práctica clínica. Revista Española de Cardiología. 2022;75(5):429.e1-429.e104. doi:10.1016/j.recesp.2021.10.016E2
  4. Masiá Mondéjar MD, López-Ruiz I, Quiles J, Sánchez Suárez L, Rubio Sanz O, Roibal Pravio J, et al. El papel del ejercicio físico en la salud cardiovascular de la mujer. Documento de posicionamiento de SEC-Asociación de Cardiología Preventiva/SEC-GT Ejercicio Físico y Salud Cardiovascular. REC: CardioClinics. 2026;61(1):57-67. doi:10.1016/j.rccl.2025.10.005I1
  5. Shoemaker MJ, Curtis AB, Vangsnes E, Dickinson MG. Triangulating Clinically Meaningful Change in the Six-minute Walk Test in Individuals with Chronic Heart Failure: A Systematic Review. Cardiopulmonary Physical Therapy Journal. 2012;23(3):5-15. doi:10.1097/01823246-201223030-00002E1

Fichas técnicas (CIMA, AEMPS) (41)

  1. Ficha técnica de atorvastatina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 61716F5
  2. Ficha técnica de atorvastatina, ácido acetilsalicílico y ramipril. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 78574F1
  3. Ficha técnica de bisoprolol. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 57655F5
  4. Ficha técnica de bupropión. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 63265E8F1
  5. Ficha técnica de carvedilol. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 59695F5
  6. Ficha técnica de citisiniclina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 83407B7
  7. Ficha técnica de citisiniclina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 88780E8F1
  8. Ficha técnica de colchicina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 78947E8F1
  9. Ficha técnica de dapagliflozina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1151052007F5
  10. Ficha técnica de empagliflozina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 114930014F5
  11. Ficha técnica de furosemida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 39969F5
  12. Ficha técnica de gliclazida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 63644F5
  13. Ficha técnica de glimepirida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 67512F5
  14. Ficha técnica de insulina asparta. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1161160001F5
  15. Ficha técnica de insulina degludec. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 112807004F5
  16. Ficha técnica de insulina glargina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 114944012F5
  17. Ficha técnica de ivabradina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 05317003F5
  18. Ficha técnica de liraglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 115992002E8
  19. Ficha técnica de liraglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 90098F1
  20. Ficha técnica de metformina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 55211F5
  21. Ficha técnica de metoprolol. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 54503F5
  22. Ficha técnica de nebivolol. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 71283B7
  23. Ficha técnica de nebivolol. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 83604F5
  24. Ficha técnica de nicotina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 57455B7
  25. Ficha técnica de nicotina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 57736F1
  26. Ficha técnica de nicotina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 65842F1
  27. Ficha técnica de nicotina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 68303E8
  28. Ficha técnica de nitroglicerina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 56574G3
  29. Ficha técnica de nitroglicerina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 57359G3
  30. Ficha técnica de rosuvastatina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 70243F5
  31. Ficha técnica de semaglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 117251002F5
  32. Ficha técnica de semaglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1211608010E8F5
  33. Ficha técnica de semaglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1211608023B7F1
  34. Ficha técnica de semaglutida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1211608025F1
  35. Ficha técnica de sildenafilo. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 74008B7
  36. Ficha técnica de tirzepatida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 1221685055B7E8F1F5
  37. Ficha técnica de torasemida. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 60450F5
  38. Ficha técnica de vareniclina. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 06360012B7E8F1
  39. Ficha técnica de ácido acetilsalicílico. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 81216E8
  40. Ficha técnica de ácido acetilsalicílico. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 81793F1G3
  41. Ficha técnica de ácido acetilsalicílico, atorvastatina y ramipril. Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), Centro de Información online de Medicamentos (CIMA). Consultada el 07/11/2026. CIMA, registro 81773E8
La lista se hace sola con lo que citan las páginas de este ESPACIO (PubMed por el PMID; el DOI, en PubMed o en Crossref; las fichas técnicas, en CIMA; los estudios en marcha, en ClinicalTrials.gov) y se rehace cada vez que se actualiza el ESPACIO; seis autores y «et al.», como pide el estilo Vancouver.

ESPACIO formativo de CardioTeca.com sobre prevención y rehabilitación. Contenidos elaborados con independencia editorial y dirigidos a profesionales sanitarios. Los fármacos se nombran por su denominación común internacional. Edita y revisa el Comité Editorial de CardioTeca. Última actualización: .

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